Mutagen Formation in the Nitrite—Piperic Acid Reaction
Mutagen Formation in the Nitrite—Piperic Acid Reaction
复制标题
亚硝酸盐-胡椒酸反应中诱变剂的形成
DOI：
10.1271/bbb1961.46.3105
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
K. Namiki
中科院分区：
文献类型：
--
作者：
T. Osawa;M. Namiki;K. Namiki
亚硝酸盐与类似于山梨酸的食品成分反应中诱变剂的形成已使用微生物诱变性测试进行了广泛研究。通过重新测定和 Amestest 检测到强烈的诱变活性，特别是在亚硝酸盐处理的胡椒碱溶液中。由于在胡椒酸-亚硝酸盐反应混合物中观察到相同的致突变性特征，因此进行了亚硝酸钠与胡椒酸的大规模反应并分离了四种致突变反应产物。主要诱变剂之一被确定为 6-硝基胡椒醛，并提出了亚硝酸盐处理胡椒碱的形成途径。
The formation of mutagens in the reaction of nitrite with food componentsanalogous to sorbic acid has been extensively investigated, using the microbial mutagenicity tests. Strong mutagenic activity was detected, especially in a nitrite-treated piperine solution, by the rec-assay and the Amestest. Because the same mutagenicity profile was observed in a piperic acid-nitrite reaction mixture, a large scale reaction of sodium nitrite with piperic acid was carried out and four mutagenic reaction products were isolated. One of the main mutagens was identified as 6- nitropiperonal and a formation pathway from nitrite-treated piperine is proposed.