DIAGNOSIS OF RABIES IN CELL-CULTURE - COMPARISON OF RESULTS FROM INOCULATION OF MOUSE NEURO-BLASTOMA CELL-CULTURE WITH RESULTS FROM THE MOUSE INOCULATION TEST
DIAGNOSIS OF RABIES IN CELL-CULTURE - COMPARISON OF RESULTS FROM INOCULATION OF MOUSE NEURO-BLASTOMA CELL-CULTURE WITH RESULTS FROM THE MOUSE INOCULATION TEST
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DOI：
10.1016/0147-9571(88)90039-2
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发表时间：
1988-01-01
影响因子：
2
通讯作者：
AUBERT, MFA
中科院分区：
文献类型：
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作者：
BARRAT, J;BARRAT, MJ;AUBERT, MFA
小鼠接种试验（MIT）是诊断狂犬病的一种高度敏感的试验，但速度慢，费用高。本文对Neuro 2a细胞培养（CC）和MIT检测狂犬病病毒及体外技术进行了比较。在一个实验室中，CC似乎总体上比MIT更敏感，然而MIT是唯一检测到一些阳性样品的实验室。在另一个实验室里，麻省理工学院更敏感。这些结果证明了CC用于流行病学诊断的合理性，但强调了MIT（参考技术）对特殊病例的兴趣。
Mouse inoculation test (MIT) is a highly sensitive test for rabies diagnosis but slow and expensive. To detect rabies virus and in vitro technique using Neuro 2a cell culture (CC) was compared with MIT in two laboratories. In one laboratory, CC appeared to be on the whole more sensitive than MIT, nevertheless MIT was the only one to detect some positive samples. In the other laboratory, MIT was more sensitive. These results justify the use of CC for epidemiological diagnosis but emphasize the interest of MIT (the reference technique) for special cases.