Selective and Real-Time Detection of Nitric Oxide by a Two-Photon Fluorescent Probe in Live Cells and Tissue Slices

Selective and Real-Time Detection of Nitric Oxide by a Two-Photon Fluorescent Probe in Live Cells and Tissue Slices
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通过双光子荧光探针选择性实时检测活细胞和组织切片中的一氧化氮

DOI:
10.1021/acs.analchem.7b02680
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发表时间:
2017-10-03
影响因子:
7.4
通讯作者:
Song, Qin-Hua
Song, Qin-Hua
中科院分区:
化学1区
文献类型:
--
作者:
Dai, Chun-Guang;Wang, Ji-Long;Song, Qin-Hua

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一氧化氮(NO)是一种重要的信号分子,参与多种生理和病理过程。在过去的20年里,人们设计了许多性能优良的NO荧光探针,但仍然存在响应慢、选择性低、激发波长短等局限性,因此,研究NO的荧光探针是研究NO的关键。
Nitric oxide (NO) is an important signaling molecule involved in many physiological and pathological processes. To understand these NO-mediated processes, it is a key to develop rapid and specific detection methods for NO. In the past 2 decades, numerous excellent fluorescent probes for NO have been designed; however, it still remains limitations such as slow response, low selectivity, and short excitation wavelength (