The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.
The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.
复制标题
DOI：
10.1093/femsre/fuaa060
复制
发表时间：
2021-05-05
影响因子：
11.3
通讯作者：
Brown AJP
中科院分区：
文献类型：
--
作者：
d'Enfert C;Kaune AK;Alaban LR;Chakraborty S;Cole N;Delavy M;Kosmala D;Marsaux B;Fróis-Martins R;Morelli M;Rosati D;Valentine M;Xie Z;Emritloll Y;Warn PA;Bequet F;Bougnoux ME;Bornes S;Gresnigt MS;Hube B;Jacobsen ID;Legrand M;Leibundgut-Landmann S;Manichanh C;Munro CA;Netea MG;Queiroz K;Roget K;Thomas V;Thoral C;Van den Abbeele P;Walker AW;Brown AJP
白色念珠菌是人类的主要真菌病原体。它作为一种寄生虫存在于大多数个体的口腔、肠道或生殖道中，受到局部微生物群、上皮屏障和免疫防御的限制。它们的扰动可导致真菌生长和粘膜感染的发展，如口咽或外阴阴道念珠菌病，免疫力受损的患者易受危及生命的全身感染。真菌、宿主和微生物群之间的相互作用在推动C.白色念珠菌对致病性的共生现象受到广泛关注。然而，这些相互作用的复杂性，以及真菌、宿主和微生物群变异性对疾病严重程度和结果的重大影响，还不太清楚。因此，我们总结了促进感染的真菌的特征，以及临床分离株之间的遗传变异如何影响致病性。我们讨论抗真菌免疫，这是如何不同的粘膜，以及如何影响一个人的易感性感染的个体差异。此外，我们还描述了影响肠道、口腔和阴道微生物菌群组成的因素，以及这些因素如何影响真菌定植和抗真菌免疫。我们认为，对这些变量的详细了解，这些变量是真菌-宿主-微生物群相互作用的基础，将为有益于弱势患者的定向抗真菌治疗提供机会。真菌病原体、其人类宿主和微生物群之间的FunHoMic相互作用的复杂性和可变性强烈影响困扰全球人类健康的浅表和系统性白色念珠菌感染的发展和结果。
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial barriers and immune defences. Their perturbation can lead to fungal outgrowth and the development of mucosal infections such as oropharyngeal or vulvovaginal candidiasis, and patients with compromised immunity are susceptible to life-threatening systemic infections. The importance of the interplay between fungus, host and microbiota in driving the transition from C. albicans commensalism to pathogenicity is widely appreciated. However, the complexity of these interactions, and the significant impact of fungal, host and microbiota variability upon disease severity and outcome, are less well understood. Therefore, we summarise the features of the fungus that promote infection, and how genetic variation between clinical isolates influences pathogenicity. We discuss antifungal immunity, how this differs between mucosae, and how individual variation influences a person's susceptibility to infection. Also, we describe factors that influence the composition of gut, oral and vaginal microbiotas, and how these affect fungal colonisation and antifungal immunity. We argue that a detailed understanding of these variables, which underlie fungal-host-microbiota interactions, will present opportunities for directed antifungal therapies that benefit vulnerable patients. The complexity and variability of FunHoMic interactions between the fungal pathogen, its human host and the Microbiota strongly influence the development and outcomes of the superficial and systemic Candida albicans infections that plague human health worldwide.
影响因子：
4.2
作者：
Kidane YH;Lawrence C;Murali TM
通讯作者：
Murali TM