Prognostic value of serum and tumor tissue CA 72-4 content in gastric cancer
Prognostic value of serum and tumor tissue CA 72-4 content in gastric cancer
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DOI：
10.1177/172460080301800104
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发表时间：
2003-01-01
影响因子：
2
通讯作者：
Guadagni, F
中科院分区：
文献类型：
--
作者：
Aloe, S;D'Alessandro, R;Guadagni, F
迄今为止，关于 CEA、CA 19-9 和 CA 72-4 作为胃癌血清标志物的预后意义尚未达成普遍共识，并且仅可获得关于肿瘤组织中标志物表达的预测价值的零散信息。因此，我们设计了一项纵向研究，分析166例不同分期胃癌患者术前血清和肿瘤组织中CA 72-4、CEA和CA 19-9的含量，并评估其与临床病理特征在无复发生存预后信息方面可能的相关性。获得的结果显示，48.4% 的肿瘤复发患者术前 CA 72-4 水平呈阳性，而未患病患者的这一比例约为 24%。此外，复发患者的术前血清 CA 72-4 中位水平显着升高。浆膜和淋巴结受累以及术前血清 CA 72-4 水平阳性在预测复发方面具有独立的预后价值。还证明了无病生存率与淋巴结受累、浸润深度和肿瘤组织 CA 72-4 含量之间的显着相关性。因此，我们可以得出结论，CA 72-4抗原可以被认为是胃癌患者随访中的选择标志物，并且可以用作复发的预后指标。
To date no general agreement has been reached regarding the prognostic significance of CEA, CA 19-9 and CA 72-4 as serum markers in gastric cancer, and only scattered information is available on the predictive value of marker expression in tumor tissue. Therefore, a longitudinal study was designed to analyze the presurgical serum and tumor tissue content of CA 72-4, CEA and CA 19-9 in 166 patients at different stages of gastric cancer, and to evaluate the possible correlation with clinicopathological features in respect to prognostic information on relapse-free survival. The results obtained showed that 48.4% of patients with tumor recurrence had positive presurgical CA 72-4 levels compared to approximately 24% of patients who remained free of disease. Furthermore, the median presurgical serum CA 72-4 levels were significantly elevated in relapsing patients. Serosa and lymph node involvement as well as positive presurgical serum-CA 72-4 levels had independent prognostic value in predicting recurrence. A significant association between disease-free survival and lymph node involvement, depth of invasion and tumor tissue content of CA 72-4 was also demonstrated. We may therefore conclude that CA 72-4 antigen can be considered the marker of choice in the follow-up of gastric cancer patients and may be used as a prognostic indicator of relapse.