A METHOD FOR ESTABLISHING A 5 ODORANT IDENTIFICATION CONFUSION MATRIX TASK IN RATS
A METHOD FOR ESTABLISHING A 5 ODORANT IDENTIFICATION CONFUSION MATRIX TASK IN RATS
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DOI：
10.1016/0031-9384(90)90352-5
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发表时间：
1990-06-01
影响因子：
2.9
通讯作者：
HORNUNG, DE
中科院分区：
文献类型：
--
作者：
YOUNGENTOB, SL;MARKERT, LM;HORNUNG, DE
使用跨模态关联范例，大鼠被训练将特定的隧道和响应位置与五种不同的气味剂（乙酸异戊酯、乙酸丙酯、乙酸、苯基醇和茴香脑）中的一种相关联。五个隧道中的每一个在以下方面不同：1）响应键上的照明图案; 2）照明图案的亮度;以及3）隧道地板的躯体感觉质量。标准的操作技术被用来训练试验启动和采样行为在中央气味呈现点。在获得训练之后，使用标准的5 × 10 - 6个细胞对动物进行测试。5混淆矩阵设计。结果首次表明，大鼠能够以高度的准确性执行类似于人类的气味识别混淆矩阵任务。此外，使用多维缩放技术，这些数据代表了可以确定动物感知气味空间的第一个实例。有了动物模型，我们就可以开始研究在神经功能障碍的情况下，一种气味是如何被错误地识别为另一种气味的。
Using a cross-modal association paradigm, rats were trained to associate a particular tunnel and response location with one of five different odorants (isoamyl acetate, propyl acetate, and acetic acid, phenyl alcohol, and anethole). Each of the five tunnels differed with respect to: 1) the illuminated pattern on the response key; 2) the brightness of the illuminated pattern; and 3) the somesthetic quality of the tunnel floor. Standard operant techniques were used to train trial initiating and sampling behavior at a central odorant presentation point. Following acquisition training, the animals were tested using a standard 5 .times. 5 confusion matrix design. The results showed for the first time that rats are capable of performing, with a high degree of accuracy, an odorant identification confusion matrix task analogous to humans. Furthermore, using multidimensional scaling techniques, these data represent the first instance in which the perceptual odor space of an animal can be determined. With the animal model in hand, we can begin to examine how, in the presence of neural dysfunction, one odorant may be incorrectly identified as another.