Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons
Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons
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DOI：
10.1016/j.neuron.2008.03.022
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发表时间：
2008-04-10
期刊：
影响因子：
16.2
通讯作者：
Zipursky, S. Lawrence
中科院分区：
文献类型：
--
作者：
Nern, Aljoscha;Zhu, Yan;Zipursky, S. Lawrence
将神经元过程组织成一系列层是许多大脑区域的标志。钙粘蛋白家族的嗜同性细胞粘附分子与层选择有关。它们如何有助于将神经元靶向不同的层仍不清楚。在这里，我们系统地探讨了一个经典的钙粘蛋白，果蝇N-钙粘蛋白（CadN），在五个类的相关神经元的一系列连续层在苍蝇视觉系统的目标的作用。我们表明，钙调蛋白是必需的在板层神经元在离散的发展步骤，但不使用层特定的方式。局部CadN表达模式与特定生长锥运动相关，并且特定层中的一个生长锥上的CadN表达对于将另一个神经元的过程靶向到该层是必不可少的。我们建议，动态调节CadN使这种广泛表达的蛋白质，以介导特定的局部相互作用，在神经回路组装。
The organization of neuronal processes into a series of layers is a hallmark of many brain regions. Homophilic cell adhesion molecules of the cadherin family have been implicated in layer choice. How they contribute to the targeting of neurons to distinct layers remains unclear. Here we systematically explore the role of a classical cadherin, Drosophila N-cadherin (CadN), in the targeting of five classes of related neurons to a series of consecutive layers in the fly visual system. We show that CadN is required in lamina neurons at discrete developmental steps but not used in a layer-specific fashion. Local CadN expression patterns correlate with specific growth cone movements, and CadN expression on one growth cone in a specific layer is essential for the targeting of processes of another neuron to this layer. We propose that dynamic regulation of CadN enables this widely expressed protein to mediate specific local interactions during neural circuit assembly.