A drug delivery system with red fluorescence for the delivery and release of 5-fluorouracil in vitro
A drug delivery system with red fluorescence for the delivery and release of 5-fluorouracil in vitro
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DOI：
10.1007/s11696-021-02028-5
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发表时间：
2022-01
期刊：
影响因子：
2.2
通讯作者：
X. Qiu;Siyu Yin;Chao Li;Yajiao Zhang;Yongxiu Li;Yufeng Chen
中科院分区：
文献类型：
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作者：
X. Qiu;Siyu Yin;Chao Li;Yajiao Zhang;Yongxiu Li;Yufeng Chen
基于Eu 3+掺杂的ZnAl-LDH的具有红色荧光的药物递送系统用于抗癌药物5-氟尿嘧啶（5-Fu）的递送和释放。5-Fu的释放在模拟肠介质（pH 7.4和37 °C的磷酸盐缓冲溶液）中进行。5-Fu的释放表现为先快速释放，平均释放速率为4.48 × 10 - 4g·L-1/min，240 min内释放70.33%;后缓慢释放，平均释放速率为9.79 × 10 - 5g·L-1/min，240 ~ 720 min释放29.67%。Eu 3+掺杂的ZnAl-LDH对5-Fu的负载容量估计为约35.0%（即每100 g Eu 3+掺杂的LDH负载35.0 g 5-Fu）。有趣的是，5-Fu负载到Eu 3+掺杂的ZnAl-LDH中使Eu 3+掺杂的ZnAl-LDH的红色荧光减弱，并且其荧光在5-Fu释放后恢复。这种红色荧光的变化可用于在特定部位的5-Fu的交付和释放的原位探测。
A drug delivery system with red fluorescence, based on Eu3+-doped ZnAl-LDH, is used for the delivery and release of the 5-fluorouracil (5-Fu) which is an anticancer drug. The release of 5-Fu was carried out in simulated intestinal medium (phosphate buffer solutions with pH 7.4 and 37 °C). The release of 5-Fu shows an initial rapid release with the average rate of 4.48 × 10−4g·L−1/min and 70.33% release within the first 240 min, followed by a slow release with the average rate of 9.79 × 10−5g·L−1/min and 29.67% release between 240 and 720 min. The loading capacity of the Eu3+-doped ZnAl-LDH for the 5-Fu was estimated to be about 35.0% (namely 35.0 g of 5-Fu per 100 g Eu3+-doped LDH). Interestingly, the loading of 5-Fu into the Eu3+-doped ZnAl-LDH attenuated the red fluorescence of the Eu3+-doped ZnAl-LDH, and its fluorescence was recovered after the 5-Fu released. This red fluorescent change may be used for in situ probing of the delivery and release of 5-Fu at specific sites.