Influence of ionotropic receptors localization on glutamatergic synaptic response to paired-pulse stimulation protocol.
Influence of ionotropic receptors localization on glutamatergic synaptic response to paired-pulse stimulation protocol.
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离子型受体定位对谷氨酸能突触对配对脉冲刺激方案反应的影响。
DOI：
10.1109/embc.2013.6609681
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Berger,TheodoreW
中科院分区：
文献类型：
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作者：
Bouteiller,Jean-MarieC;Allam,SushmitaL;Ambert,Nicolas;Greget,Renaud;Hu,Eric;Bischoff,Serge;Baudry,Michel;Berger,TheodoreW
配对脉冲方案是一种刺激模式，通常用于表征突触效力的短期变化。对此类协议的反应通常会产生不同的结果，从令人沮丧的反应到第二次脉冲后的促进反应。同样，实验结果表明，突触结构是动态的，受体沿着突触后膜移动。本研究提供了关于神经递质释放位点的谷氨酸受体定位对所测量的突触后电流的影响的见解；它还对实验观察到的反应多样性提出了解释。我们使用的平台是文献中广泛描述的 EONS/RHENOMS 建模平台，它包含大量高度详细的亚突触元素，可以最忠实地复制突触功能。
Paired-pulse protocol is a stimulation pattern that is often used to characterize short-term changes in synaptic potency. Responses to such protocol often yield varying results, going from a depressing response to a facilitated one following the second pulse. Similarly, experimental results have shown that synaptic structures are dynamic and receptors move along the postsynaptic membrane. The present study provides insights on the impact of glutamatergic receptors localization with respect to the neurotransmitters release site on the postsynaptic currents measured; it also proposes an explanation on the diversity of responses observed experimentally. The platform we used is the EONS/RHENOMS modeling platform widely described in the literature, which encompasses a multitude of highly detailed subsynaptic elements to most faithfully replicate synaptic function.