Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort
Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort
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DOI：
10.1093/ageing/afs173
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发表时间：
2013-03-01
期刊：
影响因子：
6.7
通讯作者：
Rolland, Yves
中科院分区：
文献类型：
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作者：
van Kan, Gabor Abellan;Cesari, Matteo;Rolland, Yves
背景：与年龄相关的身体成分变化和认知障碍之间存在共同的病理生理学途径。目的：评估当前的手术性肌少症定义是否与社区老年女性的认知相关。设计：横断面分析。受试者：总共 3,025 名 75 岁及以上的女性。测量：身体成分（通过双能 X 射线吸收测量法评估）和认知（通过简短的便携式精神状态问卷测量）所有参与者均获得。多变量逻辑回归模型评估了肌少症的六种手术定义与认知障碍的关联。步态速度（GS，以正常速度在 6 米跑道上测量）和握力（HG，通过手持式测力计测量）被认为是其他感兴趣的因素。结果：总共 492 名 (16.3%) 女性存在认知障碍。肌肉减少症的患病率为 3.3% 至 18.8%。在控制了潜在的混杂因素后，肌肉减少症的定义与认知障碍无关。为了证明一致性，使用 GS 和 HG 这两个公认的认知障碍预测因子进行分析。低 GS [比值比 (OR) 2.42，95% 置信区间 (Cl) 1.72-3.40] 和低 HG（OR：1.81，95% CI：1.33-2.46）与认知障碍相关。结论：不同的手术肌少症定义与认知障碍之间没有显着关联。该研究表明，身体表现与认知障碍之间的关联并非由肌肉减少症介导。
Background: common pathophysiological pathways are shared between age-related body composition changes and cognitive impairment.Objective: evaluate whether current operative sarcopenia definitions are associated with cognition in community-dwelling older women.Design: cross-sectional analyses.Subjects: a total of 3,025 women aged 75 years and older.Measurements: body composition (assessed by dual energy X-ray absorptiometry) and cognition (measured by short portable mental status questionnaire) were obtained in all participants. Multivariate logistic regression models assessed the association of six operative definitions of sarcopenia with cognitive impairment. Gait speed (GS, measured over a 6-meter track at usual pace) and handgrip strength (HG, measured by a hand-held dynamometer) were considered additional factors of interest.Results: a total of 492 (16.3%) women were cognitively impaired. The prevalence of sarcopenia ranged from 3.3 to 18.8%. No sarcopenia definition was associated with cognitive impairment after controlling for potential confounders. To proof consistency, the analyses were performed using GS and HG, two well-established predictors of cognitive impairment. Low GS [odds ratio (OR) 2.42, 95% confidence interval (Cl) 1.72-3.40] and low HG (OR: 1.81, 95% CI: 1.33-2.46) were associated with cognitive impairment.Conclusion: no significant association was evidenced between different operative sarcopenia definitions and cognitive impairment. The study suggests that the association between physical performance and cognitive impairment in not mediated by sarcopenia.