L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine.
L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine.
复制标题
左旋肉碱和酰基肉碱：用于精准医学的线粒体生物标志物。
DOI：
10.3390/metabo11010051
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发表时间：
2021-01-14
期刊：
影响因子：
4.1
通讯作者：
Stringer KA
中科院分区：
文献类型：
--
作者：
McCann MR;George De la Rosa MV;Rosania GR;Stringer KA
生物标志物的发现和实施处于精准医学运动的最前沿。代谢组学领域的现代进展为在广泛的学科中容易地鉴定新的代谢物生物标志物提供了机会。许多代谢物来源于或直接反映线粒体代谢。左旋肉碱和酰基肉碱是已建立的线粒体生物标志物，用于筛查新生儿一系列影响脂肪酸氧化的遗传疾病，称为先天性代谢缺陷。然而，L-肉毒碱和酰基肉毒碱没有常规测量超出此筛选，尽管越来越多的证据表明，它们的临床效用以外的这些疾病。肉毒碱池的测量已被用于确定疾病和疾病中的间接死亡率，如糖尿病，败血症，癌症和心力衰竭，以及确定受试者经历不良药物反应的各种药物，如丙戊酸，氯法齐明，齐多夫定，顺铂，丙泊酚和环孢素。本综述旨在收集和解释支持L-肉碱和酰基肉碱临床生物标志物应用的文献证据。对这些代谢物的进一步研究最终可以提供指导治疗决策和阐明新的药理学靶点的机制见解。
Biomarker discovery and implementation are at the forefront of the precision medicine movement. Modern advances in the field of metabolomics afford the opportunity to readily identify new metabolite biomarkers across a wide array of disciplines. Many of the metabolites are derived from or directly reflective of mitochondrial metabolism. L-carnitine and acylcarnitines are established mitochondrial biomarkers used to screen neonates for a series of genetic disorders affecting fatty acid oxidation, known as the inborn errors of metabolism. However, L-carnitine and acylcarnitines are not routinely measured beyond this screening, despite the growing evidence that shows their clinical utility outside of these disorders. Measurements of the carnitine pool have been used to identify the disease and prognosticate mortality among disorders such as diabetes, sepsis, cancer, and heart failure, as well as identify subjects experiencing adverse drug reactions from various medications like valproic acid, clofazimine, zidovudine, cisplatin, propofol, and cyclosporine. The aim of this review is to collect and interpret the literature evidence supporting the clinical biomarker application of L-carnitine and acylcarnitines. Further study of these metabolites could ultimately provide mechanistic insights that guide therapeutic decisions and elucidate new pharmacologic targets.
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影响因子：
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