Peptide Contraception: Antifertility Properties of LH‐RH Analogues
Peptide Contraception: Antifertility Properties of LH‐RH Analogues
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肽避孕：LH-RH 类似物的抗生育特性
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
F. Bex
中科院分区：
文献类型：
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作者：
A. Corbin;C. Beattie;Robert M. Jones;F. Bex
原型LH-RH拮抗剂抑制了发情前促性腺激素激增并阻断排卵，但对妊娠动物无影响。相反，LH-RH和两种高效LH-RH激动剂在植入前或植入后给药时终止妊娠。这种抗妊娠作用，以及激动剂的其他抗生殖特性，加上其作用的可逆性，强烈表明这些肽可能为避孕提供新的基础。
A prototype LH‐RH antagonist dampened the proestrous gonadotropin surge and blocked ovulation but had no effect on pregnant animals. In contrast, LH‐RH and two highly potent LH‐RH agonists terminated pregnancy when administrated prior to or following implantation. This contragestational effect, as well as other antireproductive properties of the agonists, coupled with the reversibility of their effects, strongly suggest that such peptides may provide a new basis for contraception.