Glia in Neurodegeneration: The Housekeeper, the Defender and the Perpetrator.
Glia in Neurodegeneration: The Housekeeper, the Defender and the Perpetrator.
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DOI：
10.3390/ijms21239188
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发表时间：
2020-12-02
影响因子：
5.6
通讯作者：
Cvetanovic M
中科院分区：
文献类型：
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作者：
Sheeler C;Rosa JG;Ferro A;McAdams B;Borgenheimer E;Cvetanovic M
在过去的十年里，研究揭示了神经炎症和神经变性之间的密切关系。小胶质细胞和星形胶质细胞对脑损伤的反应是建立一个多模态的炎症状态，是神经炎症结构和功能变化的主要捍卫者和刽子手。小胶质细胞和星形胶质细胞在维持正常脑功能中也起着关键作用。这种体内平衡和神经炎症功能的复杂平衡可以影响神经退行性疾病的发病和病程。小胶质-星形细胞轴在神经退行性疾病中的新兴作用提供了许多可药物靶点，可能在神经退行性疾病中具有广泛的治疗效益。在这里，我们简要回顾了小胶质细胞和星形胶质细胞的基本功能，它们在疾病状态下是如何变化的，小鼠和人类胶质细胞之间的显著差异，以及使用来自患者的人类诱导多能干细胞研究人类星形胶质细胞和小胶质细胞的细胞自主变化。
Over the past decade, research has unveiled the intimate relationship between neuroinflammation and neurodegeneration. Microglia and astrocytes react to brain insult by setting up a multimodal inflammatory state and act as the primary defenders and executioners of neuroinflammatory structural and functional changes. Microglia and astrocytes also play critical roles in the maintenance of normal brain function. This intricate balance of homeostatic and neuroinflammatory functions can influence the onset and the course of neurodegenerative diseases. The emergent role of the microglial-astrocytic axis in neurodegenerative disease presents many druggable targets that may have broad therapeutic benefits across neurodegenerative disease. Here, we provide a brief review of the basal function of both microglia and astrocytes, how they are changed in disease states, the significant differences between mouse and human glia, and use of human induced pluripotent stem cells derived from patients to study cell autonomous changes in human astrocytes and microglia.
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影响因子：
25
作者：
Galatro, Thais F.;Holtman, Inge R.;Eggen, Bart J. L.
通讯作者：
Eggen, Bart J. L.
影响因子：
5.3
作者：
Djukic, Biljana;Casper, Kristen B.;McCarthy, Ken D.
通讯作者：
McCarthy, Ken D.
影响因子：
8.8
作者：
Garcia-Reitboeck P;Phillips A;Piers TM;Villegas-Llerena C;Butler M;Mallach A;Rodrigues C;Arber CE;Heslegrave A;Zetterberg H;Neumann H;Neame S;Houlden H;Hardy J;Pocock JM
通讯作者：
Pocock JM
影响因子：
6.2
作者：
Almad AA;Doreswamy A;Gross SK;Richard JP;Huo Y;Haughey N;Maragakis NJ
通讯作者：
Maragakis NJ
影响因子：
16.6
作者：
通讯作者：
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