Relationship between Restless legs syndrome associated symptoms and presence of depression during pregnancy
Relationship between Restless legs syndrome associated symptoms and presence of depression during pregnancy
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不宁腿综合征相关症状与怀孕期间抑郁症之间的关系
DOI：
10.1080/03630242.2022.2055698
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发表时间：
2022
期刊：
影响因子：
1.6
通讯作者：
Ando Shin-ichi
中科院分区：
文献类型：
--
作者：
Sawatari Hiroyuki;Yoshimura Chikara;Amagase Hironobu;Takewaka Mizuko;Nakashima Kazuko;Imaoka Chikako;Obama Hirotsugu;Miyanaga Nanami;Ando Shin-ichi
不宁腿综合征（RLS）与一般人群中的抑郁症有关。虽然抑郁症可导致围产期的不良事件，RLS和抑郁症之间的关联仍然存在争议。因此，我们研究了抑郁症和RLS之间的关联，包括RLS相关症状，在孕妇。我们评估了存在的RLS和RLS相关的症状，在135例孕妇使用问卷调查的基础上的RLS症状艾伦的症状和国际不宁腿综合征评定量表（IRLS），分别。我们将RLS定义为艾伦症状的4/4。抑郁状态采用爱丁堡产后抑郁量表进行评估。年龄的平均值±SD为31.8 ± 4.3岁，没有参与者有RLS家族史。10%的妇女在怀孕期间患有抑郁症，IRLS评分高于无抑郁症的妇女（6.1 ± 10.5分对0.7 ± 3.8分，P= 0.001）。即使在调整混杂因素后，IRLS评分（包括其分量表）与抑郁症之间也存在显著相关性。结论是RLS相关症状可能是妊娠期抑郁的指标。需要对RLS相关症状进行全面的睡眠评估和检查，以改善怀孕期间的精神健康。
Restless legs syndrome (RLS) is associated with depression in the general population. Although depression can lead to adverse events during the perinatal period, the association between RLS and depression remains under debate. Thus, we examined the association between depression and RLS, including RLS-associated symptoms, in pregnant women. We evaluated the presence of RLS and RLS-associated symptoms in 135 pregnant women using questionnaires on RLS symptoms based on Allen’s symptoms and the International Restless Legs Syndrome Rating Scale (IRLS), respectively. We defined RLS as 4/4 on Allen’s symptoms. Depressive status was evaluated using the Edinburgh Postnatal Depression Scale. The mean±SD of age was 31.8 ± 4.3 years, and none of the participants had a family history of RLS. Ten percent of women had depression during their pregnancy and demonstrated higher IRLS scores than those without depression (6.1 ± 10.5 vs. 0.7 ± 3.8 points,P= 0.001). A significant association between IRLS score, including its subscales, and depression was observed, even after adjusting for confounders. It was concluded that RLS-associated symptoms may be indicators of depression during pregnancy. Comprehensive sleep evaluations and examinations of RLS-associated symptoms are needed to improve psychiatric health during pregnancy.