Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms
Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms
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DOI：
10.1148/radiol.2432060286
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发表时间：
2007-05-01
期刊：
影响因子：
19.7
通讯作者：
Paulsen, Keith D.
中科院分区：
文献类型：
--
作者：
Poplack, Steven P.;Tosteson, Tor D.;Paulsen, Keith D.
目的：前瞻性定量评估电磁 (EM) 特性的固有对比度，可使用现有技术对传统乳腺成像中发现异常并随后进行活检的女性进行成像。材料和方法：该方案符合 HIPAA 要求并经机构审查委员会批准。所有参与者均提供了知情同意书。使用三种 EM 成像方法对 53 名患有正常（乳房成像报告和数据系统 [BI-RADS] 1 类）的女性和 97 名患有异常（BI-RADS 4 类或 5 类）筛查乳房 X 光检查的女性进行成像：电阻抗光谱 (EIS)、微波成像光谱 (MIS) 和近红外光谱断层扫描 (NIR)。感兴趣区域 (ROI) 分析用于评估 EM 图像特性，以便将结果与传统图像结果进行比较，并与具有异常结果的女性的特定病理参数相关。进行了统计分析。结果：纳入了 150 名参与者（年龄范围，35-81 岁）。在乳房异常 ROI 中发现相对于同侧乳房背景的 EM 图像属性对比度为 150%-200%。方差分析表明，EIS、NIR 诊断组和 MIS 的乳腺 X 光检查正常与异常乳房的 ROI 图像摘要存在显着差异（分析仅限于大于 1 cm(3) 的病变）。与正常乳房受试者（BI-RADS 1 类）的 EM 特性相比，对 BI-RADS 4 类或 5 类受试者的癌症 EM 特性进行受试者工作曲线 (ROC) 分析，得出 ROC 曲线下面积范围为 0.67 至 0.81。平均血管密度、平均血管面积和上皮与间质比率的病理相关性表明与疾病相关的 EM 图像特性的生物学起源。结论：EM 乳房检查的结果提供了异常（良性和恶性）与正常乳腺组织之间图像对比度平均增加 150% 200% 的统计证据。 (c) 北美放射学会，2007 年
Purpose: To prospectively assess quantitatively the inherent contrast of electromagnetic ( EM) properties that can be imaged by using available technology in women with abnormal findings at conventional breast imaging who underwent subsequent biopsy.Materials and Methods: The protocol was HIPAA compliant and approved by the institutional review board. All participants provided informed consent. Fifty-three women with normal (Breast Imaging Reporting and Data System [BI-RADS] category 1) and ninety-seven women with abnormal (BI-RADS category 4 or 5) screening mammograms were imaged with three EM imaging methods: electrical impedance spectroscopy (EIS), microwave imaging spectroscopy (MIS), and near-infrared spectral tomography (NIR). A region-of-interest (ROI) analysis was used to assess the EM image properties for comparison of findings with conventional image findings and correlation with specific pathologic parameters for women with abnormal findings. Statistical analyses were conducted.Results: One hundred fifty participants (age range, 35-81 years) were included. EM image property contrast ratios of 150%-200% were found in breast abnormality ROIs relative to the ipsilateral breast background. Analysis of variance demonstrated significant differences in ROI image summaries of mammographically normal versus abnormal breasts for EIS, across diagnostic groups for NIR, and for MIS (analysis restricted to lesions larger than 1 cm(3)). Receiver operating curve (ROC) analysis of the EM properties for cancers among subjects with BI-RADS category 4 or 5, compared with the EM properties for the subjects with normal breasts (BI-RADS category 1), yielded areas under the ROC curve ranging from 0.67 to 0.81. Pathologic correlations with mean vessel density, mean vessel area, and epithelium-to-stroma ratio suggest a biological origin of the EM image properties associated with disease.Conclusion: Results from EM breast examinations provide statistical evidence of a mean increase in image contrast of 150% 200% between abnormal (benign and malignant) and normal breast tissue. (c) RSNA, 2007