TRPA1: A gatekeeper for inflammation.
TRPA1: A gatekeeper for inflammation.
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DOI：
10.1146/annurev-physiol-030212-183811
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发表时间：
2013
影响因子：
18.2
通讯作者：
Tsunozaki M
中科院分区：
文献类型：
--
作者：
Bautista DM;Pellegrino M;Tsunozaki M
组织损伤引起炎症反应，促进有害刺激的去除、组织修复和保护行为，以防止进一步损伤并促进愈合。然而，炎症可能会超过其有效性并成为慢性。慢性炎症可导致许多疾病，包括哮喘、瘙痒、类风湿性关节炎和结肠炎。支配靶器官的初级传入感觉神经元在组织损伤的局部区域释放炎性神经肽，以促进血管渗漏、免疫细胞的募集以及对机械和热刺激的超敏反应。TRPA1通道是神经元兴奋、炎性神经肽释放和随后的疼痛超敏反应所必需的。TRPA1还通过从组织损伤或疾病区域的非神经元细胞释放炎性物质而被激活。TRPA1作为炎症因子的检测器和煽动者的双重功能使TRPA1成为皮肤、气道和胃肠道慢性炎症性疾病的守门人。
Tissue damage evokes an inflammatory response that promotes the removal of harmful stimuli, tissue repair, and protective behaviors to prevent further damage and encourage healing. However, inflammation may outlive its usefulness and become chronic. Chronic inflammation can lead to a host of diseases, including asthma, itch, rheumatoid arthritis, and colitis. Primary afferent sensory neurons that innervate target organs release inflammatory neuropeptides in the local area of tissue damage to promote vascular leakage, the recruitment of immune cells, and hypersensitivity to mechanical and thermal stimuli. TRPA1 channels are required for neuronal excitation, the release of inflammatory neuropeptides, and subsequent pain hypersensitivity. TRPA1 is also activated by the release of inflammatory agents from nonneuronal cells in the area of tissue injury or disease. This dual function of TRPA1 as a detector and instigator of inflammatory agents makes TRPA1 a gatekeeper of chronic inflammatory disorders of the skin, airways, and gastrointestinal tract.
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DOI：
10.1152/ajpgi.00464.2006
发表时间：
2007-07-01
影响因子：
4.5
作者：
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影响因子：
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