Multiple recurrences of major depressive disorder
Multiple recurrences of major depressive disorder
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DOI：
10.1176/appi.ajp.157.2.229
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发表时间：
2000-02-01
影响因子：
17.7
通讯作者：
Endicott, J
中科院分区：
文献类型：
--
作者：
Solomon, DA;Keller, MB;Endicott, J
目的：研究单极重性抑郁障碍的多次复发。方法：在一项多中心自然主义研究中，对318例单极重性抑郁症患者进行了10年的前瞻性随访。生存分析技术用于检查指数发作恢复后复发的概率。结果：每年随访的平均重度抑郁症发作次数为0.21次，近三分之二的受试者至少复发一次。重度抑郁症终生发作次数与复发概率显著相关，每一次连续复发，复发风险增加16%。随着恢复时间的延长，复发的风险逐渐降低。在受试者中，复发时间几乎没有一致性。结论：重性抑郁症是一种高复发性疾病。重性抑郁障碍复发的风险随着每次连续发作逐渐增加，随着恢复时间的延长而降低。
Objective: The authors of this study examined multiple recurrences of unipolar major depressive disorder. Method: A total of 318 subjects with unipolar major depressive disorder were prospectively followed for 10 years within a multicenter naturalistic study. Survival analytic techniques were used to examine the probability of recurrence after recovery from the index episode. Results: The mean number of episodes of major depression per year of follow-up was 0.21, and nearly two-thirds of the subjects suffered at least one recurrence. The number of lifetime episodes of major depression was significantly associated with the probability of recurrence, such that the risk of recurrence increased by 16% with each successive recurrence. The risk of recurrence progressively decreased as the duration of recovery increased. Within subjects, there was very little consistency in the time to recurrence. Conclusions: Major depressive disorder is a highly recurrent illness. The risk of the recurrence of major depressive disorder progressively increases with each successive episode and decreases as the duration of recovery increases.