Spatial- and locomotion-related neural representation in rat hippocampus following long-term survival from ischemia.
Spatial- and locomotion-related neural representation in rat hippocampus following long-term survival from ischemia.
复制标题
缺血长期存活后大鼠海马的空间和运动相关神经表征。
DOI：
10.1037//0735-7044.109.6.1081
复制
发表时间：
1995
影响因子：
1.9
通讯作者：
Volpe,BT
中科院分区：
文献类型：
--
作者：
Mizumori,SJ;Garcia,PA;Raja,MA;Volpe,BT
在执行空间迷宫的缺血大鼠和假对照大鼠之间比较海马细胞放电的空间和运动相关行为相关性。缺血大鼠在迷宫获取过程中表现出选择准确性受损，但在渐近线表现过程中却没有表现出选择准确性受损。渐近线表现期间的单单元相关性揭示了 CA2/3 复合刺突细胞的空间选择性增强，与肺门复合刺突或下突细胞的位置特异性放电减弱相一致。颗粒层中间神经元对运动状态的响应被夸大，运动引起的肺门和皮下中间神经元放电的变化减少。缺血大鼠表现出恢复的空间学习能力，这一事实可以证明，在第二环境中获得空间任务没有受到损害。由于在缺血性迷宫实验大鼠中也观察到了表征重组，因此脑损伤本身似乎改变了信息编码方案。
Spatial and locomotion-related behavioral correlates of hippocampal cell discharge were compared between ischemic and sham-control rats performing a spatial maze. Ischemic rats showed impaired choice accuracy during maze acquisition, but not during asymptote performance. Single-unit correlates during asymptote performance revealed enhanced spatial selectivity of CA2/3 complex-spike cells coincident with attenuated place-specific firing by hilar complex-spike or subicular cells. Responsivity to locomotion state by stratum granulosum interneurons was exaggerated, and locomotion-induced changes in firing of hilar and subicular interneurons was reduced. Ischemic rats showed recovered spatial learning abilities as evidenced by the fact that acquisition of the spatial task in a second environment was not impaired. Because representational reorganization was also observed in ischemic, maze-naive rats, brain injury per se appears to change information coding schemes.