Influence of diet on the gut microbiome and implications for human health.
Influence of diet on the gut microbiome and implications for human health.
复制标题
DOI：
10.1186/s12967-017-1175-y
复制
发表时间：
2017-04-08
影响因子：
7.4
通讯作者：
Liao W
中科院分区：
文献类型：
--
作者：
Singh RK;Chang HW;Yan D;Lee KM;Ucmak D;Wong K;Abrouk M;Farahnik B;Nakamura M;Zhu TH;Bhutani T;Liao W
最近的研究表明，肠道微生物群在调节几种慢性疾病的风险方面发挥着重要作用，包括炎症性肠病、肥胖症、2型糖尿病、心血管疾病和癌症。与此同时，人们现在了解到饮食在塑造微生物群方面发挥着重要作用，实验表明，改变饮食可以在24小时内引发大规模的、暂时的微生物变化。鉴于这种联系，通过饮食改变微生物组成可能有显著的治疗作用。本综述系统地评价了目前有关几种常见饮食成分对肠道微生物区系的影响的数据。我们表明，食用特定类型的食物会在现有宿主细菌属中产生可预测的变化。此外，这些细菌的特性会影响宿主的免疫和代谢参数，对人类健康具有广泛的影响。熟悉这些联系对从业者和病人都有很大的帮助。
Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. At the same time, it is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary microbial shifts within 24 h. Given this association, there may be significant therapeutic utility in altering microbial composition through diet. This review systematically evaluates current data regarding the effects of several common dietary components on intestinal microbiota. We show that consumption of particular types of food produces predictable shifts in existing host bacterial genera. Furthermore, the identity of these bacteria affects host immune and metabolic parameters, with broad implications for human health. Familiarity with these associations will be of tremendous use to the practitioner as well as the patient.