Quantifying oncogenic phosphotyrosine signaling networks through systems biology.
Quantifying oncogenic phosphotyrosine signaling networks through systems biology.
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DOI：
10.1016/j.gde.2009.12.005
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发表时间：
2010-02
影响因子：
4
通讯作者：
White, Forest M.
中科院分区：
文献类型：
--
作者：
Del Rosario, Amanda M.;White, Forest M.
Pathways linking oncogenic mutations to increased proliferative or migratory capacity are poorly characterized, yet provide potential targets for therapeutic intervention. As tyrosine phosphorylation signaling networks are known to mediate proliferation and migration, and frequently go awry in cancers, a comprehensive understanding of these networks in normal and diseased states is warranted. To this end, recent advances in mass spectrometry, protein microarrays, and computational algorithms provide insight into various aspects of the network including phosphotyrosine identification, analysis of kinase/phosphatase-substrates, and phosphorylation mediated protein-protein interactions. Here we detail technological advances underlying these systems level approaches and give examples of their application. By combining multiple approaches, it is now possible to quantify changes in the phosphotyrosine signaling network with various oncogenic mutations, thereby unveiling novel therapeutic targets.
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影响因子：
64.8
作者：
Ptacek, J;Devgan, G;Snyder, M
通讯作者：
Snyder, M
DOI：
10.1073/pnas.1633513100
发表时间：
2003-08-05
影响因子：
11.1
作者：
Nielsen, UB;Cardone, MH;Sorger, PK
通讯作者：
Sorger, PK
影响因子：
--
作者：
Kaushansky, Alexis;Gordus, Andrew;MacBeath, Gavin
通讯作者：
MacBeath, Gavin
影响因子：
4.8
作者：
Kolli, S;Zito, CI;Bennett, AM
通讯作者：
Bennett, AM
影响因子：
9.9
作者：
Gordus, Andrew;Krall, Jordan A.;MacBeath, Gavin
通讯作者：
MacBeath, Gavin