Measles, rubella, mumps, and varicella seroprevalence among health care workers in Turkey: Is prevaccination screening cost-effective?
Measles, rubella, mumps, and varicella seroprevalence among health care workers in Turkey: Is prevaccination screening cost-effective?
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DOI：
10.1016/j.ajic.2006.04.213
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发表时间：
2006-11-01
影响因子：
4.9
通讯作者：
Dokuzoguz, Basak
中科院分区：
文献类型：
--
作者：
Celikbas, Aysel;Ergonul, Onder;Dokuzoguz, Basak
背景资料：调查卫生保健工作者（HCWs）对麻疹，风疹，腮腺炎，水痘带状疱疹（MMRV）在土耳其的免疫状况，并确定一个适当的疫苗接种计划HCWs.Methods：自愿HCWs从儿童医院和综合医院被列入2005年3月至5月的研究。结果：共调查医务人员363人，其中医生186人（51%），护士118人（33%），家政人员36人（10%），医技人员23人（6%）。医务人员麻疹抗体阳性率为98.6%，风疹抗体阳性率为98.3%，腮腺炎抗体阳性率为92.2%，水痘抗体阳性率为98%。在整个研究组或每家医院中，未发现对MMRV病毒感染的敏感性与性别、年龄、工作时间、职业和工作部门之间存在关联。水痘病史的阳性预测值为100%，而MMR的阳性预测值为92%。如果在接种疫苗前没有进行筛查，水痘疫苗的接种费用非常昂贵。结论：对工作人员进行水痘感染史筛查，对水痘感染史阴性的工作人员进行水痘疫苗接种，是一种有效的预防措施。
Background: To investigate the immune status of health care workers (HCWs) against measles, rubella, mumps, and varicella zoster (MMRV) in Turkey and to define an appropriate vaccination program among HCWs.Methods: Voluntary HCWs from a children's hospital and a general hospital were included in the study between March and May 2005. The specific IgG antibodies against MMRV viruses were screened by ELISA.Results: Three hundred sixty-three HCWs participated in the study; 186 (51%) were physicians, 118 (33%) were nurses, 36 (10%) were housekeeping staff, and 23 (6%) were medical technicians. The proportion of HCWs who had antibodies against measles was 98.6%; rubella, 98.3%; mumps, 92.2%; and varicella, 98%. No association was found between the susceptibility to at least I of MMRV virus infections and gender, age, duration of work, profession, and department of work in analysis either among the whole study group, or each hospital. The positive predictive value for the history of varicella was 100%, whereas it was 92% for MMR. The cost of vaccination for varicella was significantly expensive without screening before vaccination. However, there was not much difference for MMR infections.Conclusion: A policy based on obtaining the history of varicella infection from the staff and then screening the ones with negative history and vaccination of only seronegative HCWs was found to be appropriate.