Super-active analogs of growth hormone-releasing factor (1-29)-amide.
Super-active analogs of growth hormone-releasing factor (1-29)-amide.
复制标题
生长激素释放因子 (1-29)-酰胺的超活性类似物。
DOI：
10.1016/0006-291x(84)91647-4
复制
发表时间：
1984
影响因子：
3.1
通讯作者：
Coy,DH
中科院分区：
文献类型：
--
作者：
Lance,VA;Murphy,WA;Sueiras-Diaz,J;Coy,DH
Human pancreatic growth hormone releasing factor (1–29)-amide [hpGRF (1–29)-NH2] and the following analogs: [D-Tyr-1]-hpGRF (1–29)-NH2, [D-Ala-2]-hpGRF (1–29)-NH2, [D-Asp-3]-hpGRF (1–29)-NH2, and [N-Ac-Tyr-1]-hpGRF (1–29)-NH2were synthesized using solid phase methodology and tested for their ability to stimulate growth hormone (GH) secretion in the rat and the pig in vivo. [D-Ala-2]-hpGRF (1–29)-NH2was approximately 50 times more potent than the parent molecule in eliciting GH secretion in the rat. The other analogs were less active, but all were more potent than the 1–29 amide in the rat. [D-Tyr-1]-hpGRF (1–29)-NH2was 10 times more potent, [D-Asp-3]-hpGRF (1–29)-NH27 times more potent, and the acetylated molecule approximately 12 times more potent than hpGRF (1–29)-NH2.
