Geographical genomics of human leukocyte gene expression variation in southern Morocco.
Geographical genomics of human leukocyte gene expression variation in southern Morocco.
复制标题
摩洛哥南部人类白细胞基因表达变异的地理基因组学。
作者：
基因表达的遗传学研究揭示了解释转录本丰度变化的表达SNP。在这里，我们解决的鲁棒性eSNP协会的环境地理和人口结构的比较194个阿拉伯人和Amazigh人从一个城市和两个村庄在南部摩洛哥。高达三分之一的所有转录本的基因表达不同对之间的位置，与核糖体生物合成和氧化磷酸化显着富集。在白细胞样本中观察到346个基因的顺式eSNPs（P < 10−08）和10个基因的trans-eSNPs（P < 10−11）的强关联。在控制种族和相关性后，所有这些在三个样本地点都是一致的。没有证据表明，广泛的环境影响的大作用trans-acting介质被发现，而是遗传和环境因素在很大程度上加性的方式行事。
Studies of the genetics of gene expression reveal expression SNPs that explain variation in transcript abundance. Here we address the robustness of eSNP associations to environmental geography and population structure in a comparison of 194 Arab and Amazigh individuals from a city and two villages in southern Morocco. Gene expression differed between pairs of locations for up to a third of all transcripts, with notable enrichment for ribosomal biosynthesis and oxidative phosphorylation. Robust associations were observed in the leukocyte samples with cis-eSNPs (P < 10−08) for 346 genes, and trans-eSNPs (P < 10−11) with 10 genes. All of these were consistent across the three sample locations and after controlling for ethnicity and relatedness. No evidence for large-effect trans-acting mediators of the pervasive environmental influence was found and instead genetic and environmental factors acted in a largely additive manner.