Expressions of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor on angiogenesis in intestinal-type gastric carcinoma.
Expressions of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor on angiogenesis in intestinal-type gastric carcinoma.
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胸苷磷酸化酶（dThdPase）和血管内皮生长因子的表达对肠型胃癌血管生成的影响。
DOI：
10.3892/or.7.4.831
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
H. Ito
中科院分区：
文献类型：
--
作者：
T. Sakatani;E. Okamoto;S. Tsujitani;M. Ikeguchi;N. Kaibara;H. Ito
我们研究了胸苷磷酸化酶（dThdR）和血管内皮生长因子（VEGF）在人胃癌中的临床和病理意义，在肿瘤内微血管密度（IMVD），P53表达和患者预后方面，共128例。有dThdR或VEGF表达的癌的平均IMVD显著高于无表达的癌。胃癌组织中dThdR和VEGF的同时表达与IMVD的增加有关。VEGF表达与P53表达和患者预后不良相关，但dThdR表达与P53表达无关。
We examined the clinical and pathological significance of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor (VEGF) in human gastric carcinomas, in terms of intratumoral microvessel density (IMVD), P53 expression, and patient prognosis in a total of 128 patients. Mean IMVD was significantly higher in the carcinomas with dThdPase or VEGF expression than in carcinomas without the expression. The simultaneous expression of dThdPase and VEGF was correlated with increased IMVD of human gastric carcinomas. VEGF expression was associated with P53 expression and poor patient prognosis, but dThdPase expression was not.