Complications of androgen deprivation therapy in men with prostate cancer.
Complications of androgen deprivation therapy in men with prostate cancer.
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DOI：
10.1007/s11912-004-0051-0
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发表时间：
2004-05-01
影响因子：
4.7
通讯作者：
Petrylak, Daniel P
中科院分区：
文献类型：
--
作者：
Chen, Allen C;Petrylak, Daniel P
雄激素剥夺疗法（ADT）适用于治疗转移性前列腺癌和局部晚期疾病。除了性副作用外，长期ADT还导致其他几种变化，包括潮热;男性乳房发育;身体组成，代谢和心血管系统的变化;骨质疏松症;贫血;精神和认知问题;疲劳和生活质量下降。本文综述了ADT的这些并发症和旨在减少这些并发症的治疗方法。重要的是，临床医生要预测这些影响，并采取措施，以防止或尽量减少它们，以保持生活质量的前列腺癌幸存者。
Androgen deprivation therapy (ADT) is indicated for the treatment of metastatic prostate cancer and locally advanced disease. In addition to sexual side effects, long-term ADT results in several other changes, including hot flashes; gynecomastia; changes in body composition, metabolism, and the cardiovascular system; osteoporosis; anemia; psychiatric and cognitive problems; and fatigue and diminished quality of life. This review discusses these complications of ADT and treatments aimed at reducing them. It is important for clinicians to anticipate these effects and to initiate measures to prevent or minimize them in order to maintain quality of life in prostate cancer survivors.