Association of parental history of diabetes with cardiovascular disease risk factors in children with type 2 diabetes
Association of parental history of diabetes with cardiovascular disease risk factors in children with type 2 diabetes
复制标题
DOI：
10.1016/j.jdiacomp.2015.02.001
复制
发表时间：
2015-05-01
影响因子：
3
通讯作者：
Mayer-Davis, Elizabeth J.
中科院分区：
文献类型：
--
作者：
Law, Jennifer R.;Stafford, Jeanette M.;Mayer-Davis, Elizabeth J.
目的：确定父母糖尿病（DM）是否与2型糖尿病（T2 D）青年中不健康的心血管疾病（CVD）风险特征相关，以及相关性是否因种族/种族而异。方法：从2001年流行和2002-2005年青年糖尿病队列中的糖尿病事件中获得382名T2 D青年的家族史。父母DM以两种方式进行评估：两类-任何父母与无父母DM（总体评价并按种族/民族分层）;和四类-父母双方、仅母亲、仅父亲或无父母DM（仅总体评价）。使用回归模型检查与血红蛋白A1 c（HbA 1c）、空腹血脂、血压（BP）和尿白蛋白：肌酐比值（ACR）的关联。35.9%为男性，19.1%为非西班牙裔白色（NHW），平均T2 D持续时间为26.6 +/- 22.2个月，平均HbA 1c为7.9% +/- 2.5%（62.6 +/- 27.8 mmol/mol）。未经调整的两类比较显示，父母患有DM的青少年具有较高的HbAlc、较高的DBP和较高的ACR升高频率。调整后的两类比较显示，在ACR的非分层分析中仍存在相关性[OR（95%CI）= 2.3（1.1，5.0）]和NHW青年的HbAlc [6.8% 0.4 vs. 8.0 +/- 0.4（51.1 +/- 4.8 vs. 63.9 +/- 4.2 mmol/mol），p = .015]、DBP（67.7% 4.5 vs. 76.9 +/- 4.4 mm Hg，p = .014）和InTG（4.7 +/- 0.3 vs. 53 0.3，p = .008）。在调整后的四类evaluation.Conclusions：父母的糖尿病史可能与不健康的心血管疾病的危险因素与T2 D青年没有显着的结果。(C)2015 Elsevier Inc. All rights reserved.
Aims: Determine if 'parental diabetes (DM) is associated with unhealthier cardiovascular disease (CVD) risk profiles in youth with type 2 diabetes (T2D), and whether associations differed by race/ethnicity.Methods: Family history was available for 382 youth with T2D from 2001 prevalent and 2002-2005 incident SEARCH for Diabetes in Youth cohorts.Parental DM was evaluated in two ways: two-category-any parent vs. no parent DM (evaluated overall and stratified by race/ethnicity); and four-category-both parents, mother only, father only, or no parent DM (evaluated overall only). Associations with hemoglobin A1c (HbA1c), fasting lipids, blood pressure (BP), and urine albumin:creatinine ratio (ACR) were examined using regression models.Results: Overall, sample characteristics included: 35.9% male, 19.1% non-Hispanic white (NHW), mean T2D duration 26.6 +/- 22.2 months, mean HbA1c 7.9% +/- 2.5% (62.6 +/- 27.8 mmol/mol). Unadjusted two-category comparisons showed that youth with parental DM had higher HbAlc, higher DBP, and higher frequency of elevated ACR. Adjusted two-category comparisons showed associations remaining in non-stratified analysis for ACR [OR (95% CI) = 2.3 (1.1, 5.0)] and in NHW youth for HbAlc [6.8% 0.4 vs. 8.0 +/- 0.4 (51.1 +/- 4.8 vs. 63.9 +/- 4.2 mmol/mol), p = .015], DBP (67.7% 4.5 vs. 76.9 +/- 4.4 mm Hg, p = .014) and InTG (4.7 +/- 0.3 vs. 53 0.3, p = .008). There were no significant findings in the adjusted four-category evaluation.Conclusions: Parental history of diabetes may be associated with unhealthier CVD risk factors in youth with T2D. (C) 2015 Elsevier Inc. All rights reserved.