Cell responses to growth factors: the role of receptor tyrosine kinase intracellular domain fragments.
Cell responses to growth factors: the role of receptor tyrosine kinase intracellular domain fragments.
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细胞对生长因子的反应：受体酪氨酸激酶胞内结构域片段的作用。
DOI：
10.1126/scisignal.2003526
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发表时间：
2012
影响因子：
7.3
通讯作者：
Pozzi,Ambra
中科院分区：
文献类型：
--
作者：
Carpenter,Graham;Pozzi,Ambra
受体酪氨酸激酶（RTKs）的生长因子激活激发了典型的第二信使途径，该途径在细胞质中传递生化信号并向细胞核传递以启动细胞反应。活化rtk的胞内结构域片段（ICDs）的蛋白水解解放和这些ICDs的核易位代表了最近发现的rtk与细胞核通信的非规范机制。一些报告为ICD机制增加了以前未知的方面，并扩大了ICD作为第二信使的范围。
Growth factor activation of receptor tyrosine kinases (RTKs) provokes well-described canonical second messenger pathways that transmit biochemical signals in the cytoplasm and to the nucleus to initiate cellular responses. The proteolytic liberation of intracellular domain fragments (ICDs) from activated RTKs and the nuclear translocation of these ICDs represent a more recently identified and noncanonical mechanism by which RTKs communicate with the nucleus. Several reports have added previously unknown facets to the ICD mechanism and have enlarged the scope of ICDs as second messengers.