Pharmacokinetics of polymyxin B in an infant with multidrug-resistant Klebsiella pneumoniae bacteremia.
Pharmacokinetics of polymyxin B in an infant with multidrug-resistant Klebsiella pneumoniae bacteremia.
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多粘菌素 B 在患有多重耐药肺炎克雷伯菌菌血症的婴儿中的药代动力学。
DOI：
10.1097/inf.0b013e318207a7c1
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Tam,VincentH
中科院分区：
文献类型：
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作者：
Salvatore,ChristineM;Abdelraouf,Kamilia;Hsing,DeyinD;Tam,VincentH
我们报告了一个9个月大的婴儿静脉注射多粘菌素B治疗多重耐药肺炎克雷伯菌菌血症的经验。在稳态下获得系列血液样品，并使用经验证的液相色谱-质谱法测定血清药物浓度。发现多粘菌素B1和异亮氨酸-多粘菌素B1的消除半衰期分别为3.1和4.7小时。
We report our experience with a 9-month-old infant treated with intravenous polymyxin B for multidrug-resistant Klebsiella pneumoniae bacteremia. Serial blood samples were obtained at steady state and serum drug concentrations were determined using a validated liquid chromatography-mass spectrometry method. The elimination half-lives of polymyxin B1 and isoleucine-polymyxin B1 were found to be 3.1 and 4.7 hours, respectively.