Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.
Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.
复制标题
作者：
Herrero-Martin D;Fourtouna A;Niedan S;Riedmann LT;Schwentner R;Aryee DN
尤文氏肉瘤家族肿瘤（ESFT）的特征在于特异性染色体易位，其产生EWS-ETS嵌合蛋白。这些异常转录因子是ESFT的主要致病驱动因素。阐明影响EWS-ETS表达和/或活性的因素将指导针对这种致命疾病的新型治疗剂的开发。
Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.