Influence of Sulfoxide Group Placement on Polypeptide Conformational Stability
Influence of Sulfoxide Group Placement on Polypeptide Conformational Stability
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DOI：
10.1021/jacs.9b07223
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发表时间：
2019-09-18
影响因子：
15
通讯作者：
Deming, Timothy J.
中科院分区：
文献类型：
--
作者：
Gharakhanian, Eric G.;Bahrun, Ehab;Deming, Timothy J.
合成了一系列含五个新的非离子亚砜的多肽。亚砜基团赋予所有同系物的水溶性，这使得它们可以用作研究水中螺旋-卷曲转变的模型，同时避免带电基团或相分离的贡献。多肽被发现采用链构象在水中，这是依赖于从链骨架的亚砜的距离，整体侧链长度，和溶剂。这些结果允许制备具有不同链构象的多肽片段，而不改变化学功能，用于结构研究和功能应用中的潜在用途。
The synthesis of a homologous series containing five new nonionic sulfoxide containing polypeptides was described. Sulfoxide groups bestowed water solubility for all homologues, which allowed their use as a model for study of helix-coil transitions in water while avoiding contributions from charged groups or phase separation. Polypeptides were found to adopt chain conformations in water that were dependent on distance of sulfoxides from chain backbones, overall side-chain lengths, and solvent. These results allow preparation of polypeptide segments with different chain conformations without changing chemical functionality for potential use in structural studies and functional applications.