Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses
Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses
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塞拉利昂埃博拉病毒病暴发后期的特征：临床、病毒学、免疫学和进化分析
DOI：
10.1093/infdis/jix061
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发表时间：
2017-04-01
影响因子：
6.4
通讯作者：
Cao, Wu-Chun
中科院分区：
文献类型：
--
作者：
Jiang, Tao;Jiang, Jia-Fu;Cao, Wu-Chun
我们在2014-2015年爆发后期（2015年1月至3月）对塞拉利昂的埃博拉病例进行了埃博拉病毒疾病诊断和病毒载量估计，并分析了抗体和细胞因子水平以及病毒基因组序列。1001名患者中有86人（9.7%）确诊埃博拉病毒病，总病死率为46.8%。与存活者相比，致命病例在感染晚期与早期表现出显著更高水平的病毒载量、细胞因子和趋化因子。这些病毒在亚系3.2.4内聚集成一个新的进化枝，其病死率显著较低。
We performed Ebola virus disease diagnosis and viral load estimation for Ebola cases in Sierra Leone during the late stage of the 2014-2015 outbreak (January-March 2015) and analyzed antibody and cytokine levels and the viral genome sequences. Ebola virus disease was confirmed in 86 of 1001 (9.7%) patients, with an overall case fatality rate of 46.8%. Fatal cases exhibited significantly higher levels of viral loads, cytokines, and chemokines at late stages of infection versus early stage compared with survivors. The viruses converged in a new clade within sublineage 3.2.4, which had a significantly lower case fatality rate.