Childhood Body Composition Trajectories and Adolescent Lung Function Findings from the ALSPAC study
Childhood Body Composition Trajectories and Adolescent Lung Function Findings from the ALSPAC study
复制标题
DOI：
10.1164/rccm.201806-1168oc
复制
发表时间：
2019-07-01
影响因子：
24.7
通讯作者：
Garcia-Aymerich, Judith
中科院分区：
文献类型：
--
作者：
Peralta, Gabriela P.;Fuertes, Elaine;Garcia-Aymerich, Judith
目的：评估7-15岁儿童体重和组成轨迹与15岁时肺功能和8-15岁肺功能增长之间的关系。方法：采用基于组的轨迹建模方法，建立特定性别的身体质量指数、瘦体重指数和脂肪质量指数轨迹。这些数据来自英国Avon父母和儿童出生队列纵向研究中从6,964名儿童(49%男孩)收集的至少两次数据。在有肺功能数据的子组(n=3,575)中，使用按性别分层的多变量线性回归模型评估了这些轨迹与15年的支气管扩张后肺功能参数和8-15年的肺功能增长率的关系。测量和主要结果：对于所有的体重测量，我们确定了随着年龄的增加而增加的平行轨迹。没有一致的证据表明身体质量指数轨迹和肺功能指标之间存在关联。较高的瘦体重指数轨迹与较高的FVC、FEV1和用力呼气流量(呼吸中段)的水平和增长率相关(例如，在15岁时，瘦体重指数最高轨迹的男孩平均比最低体重轨迹的男孩的FVC高0.62FVC[95%可信区间，0.44-0.79；P趋势&0.0001])。肥胖指数的增加轨迹与FEV1和用力呼气流量、呼吸中段和FEV1/FVC的低水平和增长率有关。结论：男女儿童和青春期较高的瘦体质量与15岁时较高的肺功能一致，而较高的脂肪质量仅与较低的肺功能参数水平相关。
Rationale: Body composition changes throughout life may explain the inconsistent associations reported between body mass index and lung function in children.Objectives: To assess the associations of body weight and composition trajectories from 7 to 15 years with lung function at 15 years and lung function growth between 8 and 15 years.Methods: Sex-specific body mass index, lean body mass index, and fat mass index trajectories were developed using Group-Based Trajectory Modeling on data collected at least twice between 7 and 15 years from 6,964 children (49% boys) in the UK Avon Longitudinal Study of Parents and Children birth cohort. Associations of these trajectories with post-bronchodilation lung function parameters at 15 years and with lung function growth rates from 8 to 15 years were assessed using multivariable linear regression models, stratified by sex, in a subgroup with lung function data (n = 3,575).Measurements and Main Results: For all body mass measures we identified parallel trajectories that increased with age. There was no consistent evidence of an association between the body mass index trajectories and lung function measures. Higher lean body mass index trajectories were associated with higher levels and growth rates of FVC, FEV1, and forced expiratory flow, midexpiratory phase in both sexes (e.g., boys in the highest lean body mass index trajectory had on average a 0.62 L [95% confidence interval, 0.44-0.79; P trend < 0.0001] higher FVC at 15 yr than boys in the lowest trajectory). Increasing fat mass index trajectories were associated with lower levels and growth rates of FEV1 and forced expiratory flow, midexpiratory phase only in boys and lower levels of FEV1/FVC in both sexes.Conclusions: Higher lean body mass during childhood and adolescence is consistently associated with higher lung function at 15 years in both sexes, whereas higher fat mass is associated with lower levels of only some lung function parameters.