Response of differentiated but not anaplastic teratoma to interferon.
Response of differentiated but not anaplastic teratoma to interferon.
复制标题
分化但没有变性畸胎瘤对干扰素的反应。
DOI：
10.1038/bjc.1984.227
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发表时间：
1984-11
影响因子：
8.8
通讯作者：
Toy, J L
中科院分区：
文献类型：
--
作者：
Rustin, G J;Kaye, S B;Williams, C J;Newlands, E S;Bagshawe, K D;Toy, J L
惠康研究实验室肌肉注射类淋巴母细胞干扰素(干扰素)，每天4MU，对10例化疗耐药畸胎瘤患者进行2期试验。2例患者病情稳定，两人在接受干扰素治疗时均被认为患有分化型畸胎瘤。8例患者推测为活动性间变性生殖细胞瘤进展。其中一名15岁男孩，经活检证实为分化型畸胎瘤，接受了2个疗程的淋巴母细胞类干扰素和1个疗程的重组白细胞A干扰素(罗氏产品有限公司)。分别持续5个半月、8个月和8个多月。他对分化后的肿瘤反应不一，每次都在接受干扰素治疗期间一直维持。在他的第二个干扰素疗程中，HCG水平上升需要额外的细胞毒性化疗。淋巴母细胞类干扰素对间变性生殖细胞肿瘤似乎没有活性，但淋巴母细胞样干扰素和重组白细胞A型干扰素在治疗不能切除的分化型畸胎瘤中可能是有用的。
A Phase 2 trial was conducted using intramuscular lymphoblastoid interferon (IFN, Wellcome Research Laboratories), 4 MU per day, in 10 patients with chemotherapy-resistant teratomas. There was stabilisation of disease in 2 patients both of whom were in retrospect considered to have had differentiated teratoma at the time of IFN administration. There was progression of presumed active anaplastic germ cell tumour in 8 patients. One of these patients, a 15-year-old boy with biopsy proven differentiated teratoma has received 2 courses of lymphoblastoid IFN and 1 course of recombinant leukocyte A IFN (Roche Products Ltd.) lasting 5 1/2, 8 and 8+ months respectively. He has had a mixed response in his differentiated tumour which on each occasion has been maintained for the duration that he received IFN. Rising HCG levels during his second course of interferon required additional cytotoxic chemotherapy. Lymphoblastoid IFN does not appear to be active against anaplastic germ cell tumours but both lymphoblastoid and recombinant leukocyte A IFN may be useful in the treatment of unresectable differentiated teratoma.