Glucocorticoid level and neuropsychiatric symptoms in homosexual men with HIV infection.
Glucocorticoid level and neuropsychiatric symptoms in homosexual men with HIV infection.
复制标题
感染艾滋病毒的男同性恋者的糖皮质激素水平和神经精神症状。
DOI：
10.1176/ajp.148.1.41
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Ehrhardt,AA
中科院分区：
文献类型：
--
作者：
Gorman,JM;Kertzner,R;Cooper,T;Goetz,RR;Lagomasino,I;Novacenko,H;Williams,JB;Stern,Y;Mayeux,R;Ehrhardt,AA
有一个有争议的文献表明，压力，焦虑和抑郁对免疫系统有害，因此对健康有害。临床前研究表明，下丘脑-垂体-肾上腺（HPA）轴的应激激活可能是免疫功能低下的原因。本研究的目的是评估这种现象在人类免疫缺陷病毒（HIV）infection.MethodHomosexual男子在社区谁不符合修改后的疾病控制中心获得性免疫缺陷综合征（AIDS）的标准被招募的研究，113名男子HIV阳性，77人HIV阴性。在第一次评估时，很少有男性患有抑郁症或焦虑症。从112名HIV阳性和75名HIV阴性的男性中获得24小时尿游离皮质醇水平，这些男性的24小时尿量为500 ml或更多。皮质醇水平与措施的医疗，免疫，神经，和精神状态。Results 24小时尿游离皮质醇和医疗状况，抑郁水平，焦虑水平之间的小，但显着的相关性被发现在HIV阳性组。皮质醇水平和CD 4+或CD 8 + T淋巴细胞或CD 4-CD 8 ratio.ConclusionsAlthough HPA激活可能与HIV感染病例中的应激有关，但似乎与CD 4 + T淋巴细胞的进一步丧失无关。有最多医学并发症证据的HIV感染受试者也可能是最焦虑和抑郁的。
ObjectiveThere is a controversial literature suggesting that stress, anxiety, and depression are harmful to the immune system and therefore to health. Preclinical studies indicate that activation of the hypothalamic-pituitary-adrenal (HPA) axis by stress may be responsible for immunocompromise. The goal of this study was to assess this phenomenon in human immunodeficiency virus (HIV) infection.MethodHomosexual men in the community who did not meet modified Centers for Disease Control criteria for acquired immune deficiency syndrome (AIDS) were recruited for the study; 113 of the men were HIV positive and 77 were HIV negative. Very few of the men studied suffered from depression or anxiety disorder at the time of the first assessment. Twenty-four-hour urinary free cortisol levels were obtained from the 112 HIV-positive and 75 HIV-negative men whose 24-hour urine volumes were 500 ml or more. Cortisol levels were correlated with measures of medical, immunological, neurological, and psychiatric status.ResultsSmall but significant correlations between 24-hour urinary free cortisol and medical status, level of depression, and level of anxiety were found in the HIV-positive group. There was no relationship between cortisol level and the number of CD4+ or CD8+ T lymphocytes or the CD4-CD8 ratio.ConclusionsAlthough HPA activation may be associated with stress in cases of HIV infection, it does not seem to be associated with further loss of CD4+ T lymphocytes. Subjects with HIV infection with the most evidence of medical complications may also be the most anxious and depressed.