Perceived self-efficacy in coping with cognitive stressors and opioid activation.
Perceived self-efficacy in coping with cognitive stressors and opioid activation.
复制标题
应对认知压力源和阿片类药物激活的感知自我效能。
DOI：
10.1037//0022-3514.55.3.479
复制
发表时间：
1988
影响因子：
7.6
通讯作者：
Brouillard,ME
中科院分区：
文献类型：
--
作者：
Bandura,A;Cioffi,D;Taylor,CB;Brouillard,ME
本实验验证了在控制认知压力源时感知到的自我无能会激活内源性阿片系统的假设。受试者在完全控制认知任务要求或认知任务要求超出其认知能力的条件下进行数学运算。诱导自我效能感高的被试表现出较少的压力，而诱导自我效能感低的被试则表现出高水平的压力和自主神经兴奋。然后给受试者注射惰性生理盐水或纳洛酮，纳洛酮是一种阻断内源性阿片类镇痛作用的阿片类拮抗剂，然后测量他们的疼痛耐受水平。自我效能无压力的受试者没有阿片样物质激活的证据。在生理盐水条件下，自我无效的应激受试者能够承受越来越多的疼痛刺激。然而，当控制疼痛的内源性阿片机制被纳洛酮阻断时，受试者无法承受太多的疼痛刺激。这种变化模式表明生理盐水条件下的应激性镇痛是由内源性阿片机制介导的，并被阿片拮抗剂抵消。
This experiment tested the hypothesis that perceived self-inefficacy in exercising control over cognitive stressors activates endogenous opioid systems. Subjects performed mathematical operations under conditions in which they could exercise full control over the cognitive task demands or in which the cognitive demands strained or exceeded their cognitive capabilities. Subjects with induced high perceived self-efficacy exhibited little stress, whereas those with induced low perceived self-efficacy experienced a high level of stress and autonomic arousal. Subjects were then administered either an inert saline solution or naloxone, an opiate antagonist that blocks the analgesic effects of endogenous opiates, whereupon their level of pain tolerance was measured. The self-efficacious nonstressed subjects gave no evidence of opioid activation. The self-inefficacious stressed subjects were able to withstand increasing amounts of pain stimulation under saline conditions. However, when endogenous opioid mechanisms that control pain were blocked by naloxone, the subjects were unable to bear much pain stimulation. This pattern of changes suggests that the stress-induced analgesia found under the saline condition was mediated by endogenous opioid mechanisms and counteracted by the opiate antagonist.