Correlation of bleeding score with frequency and severity of bleeding symptoms in FXIII deficiency assessing by the ISTH Bleeding Assessment Tool
Correlation of bleeding score with frequency and severity of bleeding symptoms in FXIII deficiency assessing by the ISTH Bleeding Assessment Tool
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DOI：
10.1016/j.transci.2019.05.012
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发表时间：
2019-08-01
影响因子：
1.9
通讯作者：
Karimi, Mehran
中科院分区：
文献类型：
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作者：
Naderi, Majid;Cohan, Nader;Karimi, Mehran
目的：ISTH出血评估工具（ISTH-BAT）是为出血性疾病出血症状的标准化而开发的。本研究的目的是应用此出血分数为FXIII缺乏症患者和其关系的频率和严重程度的symptoms.Methods：在这个横断面研究中，63例严重FXIII缺乏症患者进行了评估出血分数根据标准ISTH-BAT问卷。所有患者均在伊朗扎黑丹医科大学附属的两个主要血栓和止血中心登记（50名患者）和设拉子医科大学结果：出血评分与症状数量之间存在显著相关性（r = 0.668，P < 0.001），并伴有多种严重症状（r = 0.938，P < 0.001）。结论：ISTH-BAT评分是一种可接受的出血评估工具，可用于FXIII缺乏症患者的标准化和评估。
Objectives: The ISTH bleeding assessment tool (ISTH-BAT) is developed for standardization of bleeding symptoms in bleeding disorders. The aim of this study is to apply this bleeding score for FXIII deficient patients and its relation to the frequency and severity of symptoms.Methods: In this cross-sectional study, 63 patients with severe FXIII deficiency were evaluated for the assessment of bleeding score according to the standard ISTH-BAT questionnaire. All patients were registered at two major thrombosis and hemostasis centers in Iran affiliated to Zahedan University of medical sciences (50 patients) and Shiraz University of medical sciences (13 patients).Results: Significant correlations between the bleeding score and number of symptoms (r = 0.668, P < 0.001) and with a number of severe symptoms (r = 0.938, P < 0.001) were detected. There was no significant relationship between the mean bleeding score and CNS bleeding (P = 0.390).Conclusion: The ISTH-BAT score is an acceptable bleeding assessment tool for standardization and evaluation of patients with FXIII deficiency.