Association of single nucleotide polymorphism rs3775291 in the coding region of the TLR3 gene with predisposition to tick-borne encephalitis in a Russian population
Association of single nucleotide polymorphism rs3775291 in the coding region of the TLR3 gene with predisposition to tick-borne encephalitis in a Russian population
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DOI：
10.1016/j.antiviral.2013.05.008
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发表时间：
2013-08-01
影响因子：
7.6
通讯作者：
Romaschenko, Aida G.
中科院分区：
文献类型：
--
作者：
Barkhash, Andrey V.;Voevoda, Mikhail I.;Romaschenko, Aida G.
蜱传脑炎 (TBE) 是一种中枢神经系统 (CNS) 疾病，由嗜神经、正义 RNA 病毒蜱传脑炎病毒 (TBEV) 引起。研究人员研究了俄罗斯人群 TBE 易感性与两种多态性之间可能存在的关联，即趋化因子受体 CCR5 基因编码区的 32 bp 缺失和 Toll 样受体 TLR3 基因外显子 4 的 rs3775291 单核苷酸多态性 (SNP)（G/A，Leu412Phe）。对 137 名具有不同临床表现（包括发烧 (35)、脑膜炎 (62) 和严重中枢神经系统疾病 (40)）的未免疫 TBE 患者以及对照人群（269 名随机选择的新西伯利亚公民）中的这些多态性的基因型和等位基因频率进行了分析。与对照组相比，THE患者TLR3 G等位基因和GIG纯合子的频率显着高于对照组（分别P = 0.029和0.037），特别是在重症患者中（分别P = 0.018和0.017）。这些结果表明，TLR3 rs3775291 SNP 的 G 等位基因（在 GIG 纯合基因型内）与俄罗斯人群中 TBE 的易感性相关。 (C) 2013 Elsevier B.V. 保留所有权利。
Tick-borne encephalitis (TBE) is a central nervous system (CNS) disease caused by the neurotropic, positive-sense RNA virus, tick-borne encephalitis virus (TBEV). A possible association between predisposition to TBE in a Russian population and two polymorphisms, a 32 bp deletion in the coding region of the chemokine receptor CCR5 gene and the rs3775291 single nucleotide polymorphism (SNP) (G/A, Leu412Phe) in exon 4 of the toll-like receptor TLR3 gene, was investigated. The genotypic and allelic frequencies of these polymorphisms were analyzed in 137 non-immunized TBE patients with different clinical manifestations, including fever (35), meningitis (62), and severe CNS disease (40), as well as in a control population (269 randomly selected Novosibirsk citizens). The frequencies of the TLR3 G allele and GIG homozygotes were significantly higher among the patients with THE compared with the control group (P = 0.029 and 0.037, respectively), especially among patients with severe disease (P = 0.018 and 0.017, respectively). These results indicate that the G allele (within the GIG homozygous genotype) of the TLR3 rs3775291 SNP is associated with predisposition to TBE in the Russian population. (C) 2013 Elsevier B.V. All rights reserved.