FUNCTION OF KIDNEY IN ADULT PATIENTS WITH COOLEYS DISEASE - PRELIMINARY REPORT
FUNCTION OF KIDNEY IN ADULT PATIENTS WITH COOLEYS DISEASE - PRELIMINARY REPORT
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DOI：
10.1159/000180452
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发表时间：
1975-01-01
期刊：
影响因子：
2.5
通讯作者：
ALFONSO, L
中科院分区：
文献类型：
--
作者：
MASTRANGELO, F;LOPEZ, T;ALFONSO, L
库利氏病成人患者的肾功能迄今尚未得到充分研究。对10例重型地中海贫血患者的肾小球滤过率、肾血流量、肾血浆流量及尿浓缩能力进行了研究。作者强调了某些病理变化，如肾血浆流量增加和尿液浓缩能力下降。根据肾活检，讨论了两种发病理论：逆流系统的功能障碍和髓质组织纤维化。
The function of the kidney in adult subjects with Cooley’s disease has been hitherto inadequately investigated. In 10 patients suffering from thalassemia major, glomerular filtration rate, renal plasma flow, renal blood flow have been studied, together with urine concentration capacity. The authors emphasize certain pathological changes, such as the increase in renal plasma flow and the failure of the urine concentration ability. On the basis of renal biopsies, two pathogenetic theories are discussed: the functional impairment of the countercurrent system and fibrosis of the medullary tissue.