Serum copeptin in children exposed to maltreatment
Serum copeptin in children exposed to maltreatment
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DOI：
10.1111/pcn.12412
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发表时间：
2016-10-01
影响因子：
11.9
通讯作者：
Grassi-Oliveira, Rodrigo
中科院分区：
文献类型：
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作者：
Coelho, Roberta;Levandowski, Mateus L.;Grassi-Oliveira, Rodrigo
儿童期虐待（CM）与应激反应的持续重编程有关。和肽素是下丘脑-垂体-肾上腺轴激活的标志物;然而，很少有研究检测暴露于CM的儿童的和肽素水平。本研究的目的是比较血清和肽素水平的儿童报告虐待和/或忽视和儿童没有CM的历史。MethodsThis研究包括65名儿童的中度至重度CM的积极历史，报告自己和他们的父母（S）在临床采访中，和71名儿童没有CM的历史作为对照组。根据儿童报告的暴露于性虐待、身体虐待、情感虐待、情感忽视和/或身体忽视相关事件的频率，将CM视为中度至重度。采用儿童行为量表（CBCL）评估儿童精神病理学症状。我们测量血清和肽素浓度使用酶联免疫吸附试验。ResultsChildren暴露于CM表现出较高水平的血清和肽素相比，没有CM的儿童时，控制性别，年龄和精神疾病的发病率。CBCL总分，包括内化和外化症状，在CM儿童中较高。我们没有发现和肽素和CBCL评分的内在症状和外在symptoms.Conclusion CM与和肽素血清水平独立的年龄，性别和症状的严重程度之间的相关性。和肽素是有虐待和/或忽视史儿童的一种有前途的新生物标志物。
AimChildhood maltreatment (CM) has been related to a persistent reprograming of stress-response. Copeptin is a marker of hypothalamic-pituitary-adrenal axis activation; however, few studies have examined copeptin levels in children exposed to CM. The aim of this study was to compare serum copeptin levels in children reporting child abuse and/or neglect and children with no history of CM.MethodsThis study included 65 children with a positive history of moderate to severe CM, as reported by themselves and their parent(s) during a clinical interview, and 71 children with no history of CM as a comparison group. CM was considered moderate to severe based on the child-reported frequency of being exposed to events related to sexual abuse, physical abuse, emotional abuse, emotional neglect, and/or physical neglect. Child psychopathology symptoms were assessed using the Child Behavior Checklist (CBCL). We measured serum copeptin concentration using enzyme-linked immunosorbent assay.ResultsChildren exposed to CM exhibited higher levels of serum copeptin compared to children without CM when controlling for sex, age, and psychiatric morbidity. The CBCL total score, including internalizing and externalizing symptoms, was higher in children with CM. We found no correlation between copeptin and CBCL scores for internalizing symptoms and externalizing symptoms.Conclusion CM is associated with copeptin serum levels independently of age, sex, and symptom severity. Copeptin is a promising new biomarker for children with a history of abuse and/or neglect.