Antiluteolytic strategies to improve fertility in cattle
Antiluteolytic strategies to improve fertility in cattle
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DOI：
10.1016/s0093-691x(01)00646-x
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发表时间：
2001-12-01
期刊：
影响因子：
2.8
通讯作者：
Baruselli, PS
中科院分区：
文献类型：
--
作者：
Binelli, M;Thatcher, WW;Baruselli, PS
在妊娠早期，“关键期”可定义为第15 - 17天。与这一时期相关的胚胎死亡率给养牛业造成了重大的经济损失。在此期间，子宫内膜将遵循默认程序释放PGF（2 α）的黄体溶解脉冲，除非孕体发出适当的抗黄体溶解信号来阻断PGF（2 α）的产生。妊娠的维持依赖于成功阻断子宫内膜PGF（2 α）的产生。关键期的生物学是复杂的、多因素的。来自母体和孕体的内分泌、细胞和分子因素共同决定黄体溶解或妊娠维持是否占上风。了解这些因素在关键期生物学中的影响，使研究人员能够制定一系列旨在有利于维持妊娠而不是黄体溶解的策略，策略包括激素和营养操作，以降低雌二醇17 β（E-2）的血浆浓度，同时增加孕酮（P-4）的血浆浓度，以及在关键期抑制子宫内膜中PGF（2 α）合成酶机制。实验结果表明，使用这些策略提高了人工授精和胚胎移植计划后的妊娠率。(C)2001年，Elsevier Science Inc.
During early pregnancy, a "critical period" may be defined between Days 15 and 17. Embryonic mortality associated with this period causes significant economic losses to the cattle industry. During this period, the endometrium will follow a default program to release luteolytic pulses of PGF(2 alpha), unless the conceptus sends appropriate antiluteolytic signals to block PGF(2 alpha) production. Maintenance of pregnancy is dependent on a successful blockage of endometrial PGF(2 alpha) production. Biology of the critical period is complex and multifactorial. Endocrine, cellular and molecular factors, both from maternal and conceptus origins act in concert to determine whether luteolysis or maintenance of pregnancy will prevail. Understanding the influences of such factors in the biology of the critical period allowed researchers to produce a series of strategies aiming to favor maintenance of pregnancy in lieu of luteolysis, Strategies include hormonal and nutritional manipulations to decrease plasma concentrations of estradiol 17 beta (E-2) while increasing those of progesterone (P-4), and inhibiting the PGF(2 alpha)-synthesizing enzymatic machinery in the endometrium during the critical period. Experimental results indicate that use of such strategies has improved pregnancy rates following artificial insemination and embryo transfer programs. (C) 2001 by Elsevier Science Inc.