Development and function of TH17 cells in health and disease
Development and function of TH17 cells in health and disease
复制标题
DOI：
10.1016/j.jaci.2009.04.003
复制
发表时间：
2009-05-01
影响因子：
14.2
通讯作者：
Malefyt, Rene de Waal
中科院分区：
文献类型：
--
作者：
Louten, Jennifer;Boniface, Katia;Malefyt, Rene de Waal
T(H)17 细胞是 T-H 细胞家族的最新成员，其特点是能够产生特定细胞因子，如 IL-17、IL-22、IL-17F 和 CCL20。在这篇综述中，在小鼠和人类系统中定义了 T(H)17 细胞的分化条件，并讨论了 T(H)17 特异性细胞因子和转录因子。从功能上讲，T(H)17 细胞作为一种新的效应 T-H 细胞亚群有助于宿主防御，通过对免疫和非免疫细胞的活动来防御细胞外细菌。然而，它们的活动对于病理条件下自身免疫性疾病的发展也至关重要。 T(H)17细胞也开始与过敏性疾病的发生和病理生理学相关，例如过敏性接触性皮炎、特应性皮炎和哮喘。淋巴组织诱导样细胞和自然杀伤样细胞（称为 ROR gamma t(+)NKp46(+) 或 NK-22 细胞）也可能在过敏性疾病中发挥作用，因为它们倾向于产生 IL-17 和 IL-22。 (J 过敏临床免疫学杂志 2009 年；123:1004-11。)
T(H)17 cells are the newest member of the T-H cell family and are characterized by their ability to produce specific cytokines such as IL-17, IL-22, IL-17F, and CCL20. In this review, conditions for the differentiation of T(H)17 cells are defined in both murine and human systems, with discussion of T(H)17-specific cytokines and transcription factors. Functionally, T(H)17 cells contribute to host defense as a new effector T-H cell subset with a role in protection against extracellular bacteria through activities on immune and nonimmune cells. Their activities, however, are also pivotal in the development of autoimmune diseases under pathologic conditions. T(H)17 cells are also beginning to be associated with the development and pathophysiology of allergic diseases, such as allergic contact dermatitis, atopic dermatitis, and asthma. Lymphoid tissue inducer-like cells and natural killer-like cells, termed ROR gamma t(+)NKp46(+) or NK-22 cells, might also play a role in allergic diseases because of their propensity to produce IL-17 and IL-22. (J Allergy Clin Immunol 2009;123:1004-11.)