Post-training amphetamine administration enhances memory consolidation in appetitive Pavlovian conditioning: Implications for drug addiction
Post-training amphetamine administration enhances memory consolidation in appetitive Pavlovian conditioning: Implications for drug addiction
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DOI：
10.1016/j.nlm.2006.04.005
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发表时间：
2006-11-01
影响因子：
2.7
通讯作者：
Setlow, Barry
中科院分区：
文献类型：
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作者：
Simon, Nicholas W.;Setlow, Barry
有人提出，滥用精神兴奋药物（例如安非他明）的某些成瘾潜力可能是由于它们能够通过记忆巩固作用来增强对药物相关经历的记忆。该实验检验了安非他明是否可以特异性增强中性条件刺激（CS-a光）和奖励性非条件刺激（美国食物）之间巴甫洛夫关联的记忆巩固，因为这种巴甫洛夫条件在药物成瘾中起着重要作用。雄性 Long-Evans 大鼠接受了 6 次训练，其中包括 8 次 CS 演示，然后将食物放入凹进的食物杯中。第1次、第3次和第5次训练后，大鼠在训练后立即皮下注射安非他明（1.0或2.0mg/kg）或盐水载体。使用CS期间大鼠在食物杯中花费的时间相对于CS前基线期的百分比来评估条件反应。两个安非他明治疗组都比盐水对照组表现出明显更高的选择性条件反应。在对照实验中，训练后 2 小时给予盐水、1.0 或 2.0mg/kg 安非他明的组之间没有差异，这表明训练后立即服用安非他明特别是通过记忆巩固作用而不是通过非记忆过程来增强表现。该过程模拟了与药物成瘾相关的巴甫洛夫学习，其中药物奖励的情绪效价被转移到中性药物预测刺激，例如药物用具。这些数据表明，安非他明可能通过专门针对记忆巩固的作用来增强其成瘾潜力。 (c) 2006 Elsevier Inc. 保留所有权利。
It has been suggested that some of the addictive potential of psychostimulant drugs of abuse such as amphetamine may result from their ability to enhance memory for drug-related experiences through actions on memory consolidation. This experiment examined whether amphetamine can specifically enhance consolidation of memory for a Pavlovian association between a neutral conditioned stimulus (CS-a light) and a rewarding unconditioned stimulus (US food), as Pavlovian conditioning of this sort plays a major role in drug addiction. Male Long-Evans rats were given six training sessions consisting of 8 CS presentations followed by delivery of the food into a recessed food cup. After the 1st, 3rd, and 5th session, rats received subcutaneous injections of amphetamine (1.0 or 2.0mg/kg) or saline vehicle immediately following training. Conditioned responding was assessed using the percentage of time rats spent in the food cup during the CS relative to a pre-CS baseline period. Both amphetamine-treated groups showed significantly more selective conditioned responding than saline controls. In a control experiment, there were no differences among groups given saline, 1.0 or 2.0mg/kg amphetamine 2 h post-training, suggesting that immediate post-training amphetamine enhanced performance specifically through actions on memory consolidation rather than through non-mnemonic processes. This procedure modeled Pavlovian learning involved in drug addiction, in which the emotional valence of a drug reward is transferred to neutral drug-predictive stimuli such as drug paraphernalia. These data suggest that amphetamine may contribute to its addictive potential through actions specifically on memory consolidation. (c) 2006 Elsevier Inc. All rights reserved.