Serum fatty acids and progression from dengue fever to dengue haemorrhagic fever/dengue shock syndrome.
Serum fatty acids and progression from dengue fever to dengue haemorrhagic fever/dengue shock syndrome.
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DOI：
10.1017/s0007114518002039
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发表时间：
2018-10
期刊：
影响因子：
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通讯作者：
Herrán OF
中科院分区：
文献类型：
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作者：
Villamor E;Villar LA;Lozano-Parra A;Herrera VM;Herrán OF
多不饱和脂肪酸（PUFA）可能调节炎症反应参与发展严重登革热。我们的目的是研究诊断为登革热（DF）的患者血清PUFA浓度是否与进展为登革出血热/登革休克综合征（DHF/DSS）的风险相关。第二个目的是评估DF患者中脂肪酸（FA）和炎症生物标志物之间的相关性。我们对急性发作期间随访的DF患者进行了一项前瞻性病例对照研究。我们使用无条件逻辑回归比较了109例进展为DHF/DSS的病例和235例未进展的DF对照者发热时个体FA占总FA浓度的百分比分布。我们估计了基线FA和细胞因子浓度之间的相关性，并在一个亚组中比较了急性发作和bbb1康复后的FA浓度。二十二碳六烯酸（DHA）与DHF/DSS的进展呈正相关（五分位数中DHA的多变量调整优势比[AOR] = 5.34, 95%可信区间[CI]: 2.03, 14.1； P，趋势= 0.007）。双homo-γ-亚麻酸（DGLA）与病情进展呈负相关（5分位数的AOR vs. 1 = 0.30, 95% CI: 0.13, 0.69； P，趋势= 0.007）。五酸浓度与DHF/DSS呈负相关。在基线时，PUFA与细胞因子的相关性较低。急性发作时PUFA低于无病期。总之，DF患者的血清DHA预测发展为DHF/DSS的几率较高，而DGLA和五酸预测的几率较低。
Polyunsaturated fatty acids (PUFA) might modulate inflammatory responses involved in the development of severe dengue. We aimed to examine whether serum PUFA concentrations in patients diagnosed with dengue fever (DF) were related to the risk of progression to dengue hemorrhagic fever / dengue shock syndrome (DHF/DSS). A secondary aim was to assess correlations between fatty acids (FA) and inflammatory biomarkers in DF patients. We conducted a prospective case-control study nested within a cohort of DF patients who were followed during the acute episode. We compared the distribution of individual FA % of total FA concentration at onset of fever between 109 cases who progressed to DHF/DSS and 235 DF non progressing controls using unconditional logistic regression. We estimated correlations between baseline FA and cytokine concentrations, and compared FA concentrations between the acute episode and >1 y post-convalescence in a subgroup. Docosahexaenoic acid (DHA) was positively related to progression to DHF/DSS (multivariable adjusted odds ratio [AOR] for DHA in quintile 5 vs. 1 = 5.34, 95% confidence interval [CI]: 2.03, 14.1; P, trend = 0.007). Dihomo-γ-linolenic acid (DGLA) was inversely associated with progression (AOR for quintile 5 vs. 1 = 0.30, 95% CI: 0.13, 0.69; P, trend = 0.007). Pentadecanoic acid concentrations were inversely related to DHF/DSS. Correlations of PUFA with cytokines at baseline were low. PUFA were lower during the acute episode than in a disease-free period. In conclusion, serum DHA in DF patients predicts higher odds of progression to DHF/DSS whereas DGLA and pentadecanoic acid predict lower odds.