FETAL RISK OF ANESTHESIA AND SURGERY DURING PREGNANCY
FETAL RISK OF ANESTHESIA AND SURGERY DURING PREGNANCY
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DOI：
10.1097/00000542-198606000-00019
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发表时间：
1986-06-01
期刊：
影响因子：
8.8
通讯作者：
GREER, N
中科院分区：
文献类型：
--
作者：
DUNCAN, PG;POPE, WDB;GREER, N
为了确定妊娠期间麻醉和手术对胎儿的风险，使用马尼托巴省[加拿大]的健康保险数据进行了一项研究（1971 - 1978）。根据母亲年龄和居住地区，将2，565名在妊娠期间接受意外手术的女性（A组）与未接受手术的妊娠女性（B组）配对。这两组都与一个单独维护的省级先天性异常登记处联系起来，以确定异常的频率。两组之间的先天性畸形率无显著差异，这意味着没有强烈的致畸作用。然而，在孕早期或孕中期接受全身麻醉手术的患者中，自然流产的风险增加，最明显的是在妇科手术后（估计风险比= 2.00），但在解剖学上远离孕体的手术后（估计风险比= 1.54）。虽然可以得出结论，全身麻醉手术与较高的流产率有关，但目前尚不清楚哪些因素导致观察到的胎儿风险增加。
In an attempt to define the risk to the fetus associated with anesthesia and surgery during pregnancy, a study was performed using health insurance data from the province of Manitoba [Canada] (1971 to 1978). Each of the 2,565 women undergoing incidental surgery during pregnancy (Group A) was paired with a pregnant female not undergoing surgery (Group B) by maternal age and area of residence. Both groups were linked to a separately maintained provincial congenital-anomalies registry to ascertain the frequency of anomalies. There was no significant difference in the rate of congenital anomalies between the two groups, implying no strong teratogenic effect. However, there was an increased risk of spontaneous abortion in those undergoing surgery with general anesthesia in the first or second trimester, most notably after gynecologic procedures (estimated risk ratio = 2.00), but also following procedures anatomically remote from the conceptus (estimated risk ratio = 1.54). While it is concluded that surgery with general anesthesia is associated with a higher incidence of abortion, it is conjectural at present which factor(s) account for the observed increase in fetal risk.