The push-pull action of dopamine on spatial tuning of the monkey retina:: the effects of dopaminergic deficiency and selective D1 and D2 receptor ligands on the pattern electroretinogram.
The push-pull action of dopamine on spatial tuning of the monkey retina:: the effects of dopaminergic deficiency and selective D1 and D2 receptor ligands on the pattern electroretinogram.
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DOI：
10.1016/s0042-6989(98)00028-5
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发表时间：
1998-05-01
期刊：
影响因子：
1.8
通讯作者：
Tzelepi, A
中科院分区：
文献类型：
--
作者：
Bodis-Wollner, I;Tzelepi, A
使用全身 MPTP 或 6-OHDA 消耗猴子的视网膜多巴胺会导致视网膜电图 (ERG) 对峰值空间频率刺激的反应减弱。灵长类动物视网膜中已发现多种多巴胺受体。使用氟哌啶醇（一种混合拮抗剂）、L-舒必利（D-2 拮抗剂）和 CY 208-243（一种 D-1 激动剂）进行的 ERG 研究会导致空间频率依赖性的不同效应。正常空间对比度响应 PERG 的“调整”通过将峰值空间频率处的响应幅度除以低空间频率响应的幅度来量化，得到大于 1 的数字。药理学实验的调谐是通过将正常峰值响应处获得的实际幅度除以低空间频率响应处的实际幅度来定义的。 PERG 空间对比度响应函数被讨论为视网膜神经节细胞或平均或“等效”视网膜神经节细胞的包络输出。然而，我们假设两类神经节细胞存在两条不同权重的多巴胺敏感通路。据推测，D-1 受体主要影响具有大中心的神经节细胞的“周围”组织，而 D-2 突触后受体则有助于放大具有较小中心的神经节细胞的“中心”反应。这些推论与一些低等脊椎动物的数据是一致的。还推断低亲和力 D-2 自身受体可能参与 D-1“周围”途径。了解视网膜 D-1 和 D-2 受体执行的逻辑可能有助于辨别中枢神经系统其他部位的 DA 回路中不同多巴胺受体的功能作用。 (C) 1998 年由爱思唯尔科学有限公司出版。保留所有权利。
Retinal dopamine depletion in monkeys using either systemic MPTP or 6-OHDA results in attenuated electroretinographic (ERG) responses to peak spatial frequency stimuli. Diverse dopamine receptors have been identified in the primate retina. ERG studies performed using Haloperidol (a mixed antagonist), L-Sulpiride (D-2 antagonist) and CY 208-243 (a D-1 agonist) cause spatial frequency dependent diverse effects. 'Tuning' of the normal spatial contrast response PERG, was quantified by dividing the amplitude of the response at the peak spatial frequency with the amplitude to the low spatial frequency response yielding a number greater than one. Tuning for the pharmacological experiments was defined by dividing the actual amplitude obtained at the normal peak response with the actual amplitude at the low spatial frequency response. The PERG spatial contrast response function is discussed as the envelope output of retinal ganglion cells or the average or 'equivalent' retinal ganglion cell. However, we postulate the existence of two dopamine sensitive pathways with different weights for two classes of ganglion cells. It is inferred that D-1 receptors are primarily affecting the 'surround' organization of ganglion cells with large centers, while D-2 post-synaptic receptors contribute to 'center' response amplification of ganglion cells with smaller centers. These inferences are consistent with some lower vertebrate data. It is also inferred that low affinity D-2 autoreceptors may be involved in the D-1 'surround' pathway. An understanding of the logic performed by retinal D-1 and D-2 receptors may be useful to discern the functional role of diverse dopamine receptors in DA circuits elsewhere in the CNS. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.