Pathological prognostic factors predicting lymph node metastasis in submucosal invasive (T1) colorectal carcinoma
Pathological prognostic factors predicting lymph node metastasis in submucosal invasive (T1) colorectal carcinoma
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DOI：
10.1038/modpathol.2010.88
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发表时间：
2010-08-01
期刊：
影响因子：
7.5
通讯作者：
Umemura, Satoshi
中科院分区：
文献类型：
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作者：
Tateishi, Yoko;Nakanishi, Yukihiro;Umemura, Satoshi
多达 16% 的粘膜下浸润性结直肠癌患者发生淋巴结转移。我们对 322 例连续接受根治性结肠切除术和淋巴结清扫的粘膜下浸润性结直肠癌患者进行了组织病理学因素与淋巴结转移之间的关联性研究，以在不测量粘膜下浸润深度的情况下发现淋巴结转移高风险的患者。 322例黏膜下浸润性结直肠癌患者中，46例（14.3%）发现淋巴结转移。单变量分析显示，以下组织病理学因素对淋巴结转移有显着影响：浸润深度、淋巴管浸润、静脉浸润、肿瘤分化、粘膜内肿瘤成分的生长方式、肿瘤侵袭导致的粘膜肌层完全破坏以及粘膜下浸润前沿的肿瘤出芽。多变量分析显示淋巴管侵犯（P
Lymph node metastasis occurs in as many as 16% of patients with submucosal invasive colorectal carcinoma. We investigated the association between histopathological factors and lymph node metastases in 322 consecutive patients with submucosal invasive colorectal carcinoma who had undergone radical colectomy with lymph node dissection to detect patients at high risk of lymph node metastasis without measuring the depth of submucosal invasion. Lymph node metastasis was found in 46 (14.3%) of 322 patients with submucosal invasive colorectal carcinoma. Univariate analysis showed that each of the following histopathological factors had a significant influence on lymph node metastasis: invasion depth, lymphatic invasion, venous invasion, tumor differentiation, growth pattern of the intramucosal tumor component, complete disruption of the muscularis mucosa due to tumor invasion, and tumor budding at the submucosal invasive front. Multivariate analysis showed that lymphatic invasion (P