Association of short sleep duration and rapid decline in renal function.
Association of short sleep duration and rapid decline in renal function.
复制标题
DOI：
10.1016/j.kint.2015.12.048
复制
发表时间：
2016-06
影响因子：
19.6
通讯作者：
Forman JP
中科院分区：
文献类型：
--
作者：
McMullan CJ;Curhan GC;Forman JP
肾脏受昼夜节律的影响，并被带入睡眠-觉醒周期，从而允许在整个24小时周期中预测肾脏的代谢和生理需求。虽然睡眠中断在心血管和代谢疾病中已被广泛研究，但其与慢性肾脏疾病的关系尚未得到证实。我们在一项前瞻性队列研究中对来自护士健康研究的4238名参与者进行了研究，并分析了11年期间（1989年至2000年）自我报告的睡眠时间与肾功能下降的相关性。睡眠时间较短的人更有可能经历肾小球滤过率的快速下降（30%或更多）。与每晚睡7-8小时相比，肾功能快速下降的校正比值比为1.79（95%CI，1.06-3.03）每晚睡眠5小时或更少，显著高于1.31（95% CI，1.01- 1.71），但不显著0.88（95% CI，0.50-1.57），每晚睡眠时间为9小时或以上。同样，对于每晚睡眠5小时或更少、每晚6小时、每晚7-8小时的个体，估计肾小球滤过率的校正年化下降趋势显著，分别为1.2 ml/min/1.73 m2/年、0.9 ml/min/1.73 m2/年、0.8 ml/min/1.73 m2/年和0.8 ml/min/1.73 m2/年，和每晚9小时或以上。因此，较短的睡眠持续时间与肾功能下降较快具有前瞻性和独立性。
The kidney is influenced by circadian rhythms, and entrained to the sleep-wake cycle allowing anticipation of the metabolic and physiological demands of the kidney throughout a 24-hour cycle. Although sleep disruption has been studied extensively in cardiovascular and metabolic disease, its association with chronic kidney disease has not been shown. We examined this in a prospective cohort study of 4238 participants from the Nurses’ Health Study and analyzed the association of self-reported sleep duration with decline in renal function over an 11year period (1989 to 2000). Individuals who reported shorter sleep duration were more likely to experience a rapid decline in estimated glomerular filtration rate (30% or more). Compared with sleeping 7–8 hours per night, the adjusted odds ratios for a rapid decline in renal function were a significant 1.79 (95% CI, 1.06–3.03) for 5 hours or less sleep per night, a significant 1.31 (95% CI, 1.01– 1.71) for 6 hours sleep per night, but an insignificant 0.88 (95% CI, 0.50–1.57) for 9 or more hours sleep per night. Similarly, there was a significant trend in the adjusted annualized decline in estimated glomerular filtration rate of 1.2 ml/min/1.73m2/year, 0.9 ml/min/1.73m2/year, 0.8 ml/min/1.73m2/year, and 0.8ml/min/1.73m2/year for individuals sleeping 5 hours or less per night, 6 hours per night, 7–8 hours per night, and 9 hours or more per night, respectively. Thus, shorter sleep duration is prospectively and independently associated with faster decline in renal function.