Determinants of hepatitis B and delta virus host tropism.
Determinants of hepatitis B and delta virus host tropism.
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DOI：
10.1016/j.coviro.2015.06.004
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发表时间：
2015-08
影响因子：
5.9
通讯作者：
Ploss A
中科院分区：
文献类型：
--
作者：
Winer BY;Ploss A
B型肝炎病毒（HBV）感染是一个全球性的健康问题，困扰着大约3.6亿患者。在这些人中，有1500万至2000万人同时感染了丁型肝炎病毒（HDV）。HBV的高度限制性宿主嗜性阻碍了治愈性治疗的进展，HBV仅限于人类和黑猩猩的生产性感染。在这里，我们将讨论不同的方法，已采取研究HBV和HDV感染的体内。转基因和人源化小鼠的发展使人们对HBV的发病机制有了更深入的了解。进一步了解HBV和HDV种属嗜性的决定因素将有助于构建HBV/HDV遗传易感性的小动物模型。
Hepatitis B virus (HBV) infections are a global health problem afflicting approximately 360 million patients. Of these individuals, 15–20 million are co-infected with hepatitis delta virus (HDV). Progress towards curative therapies has been impeded by the highly restricted host tropism of HBV, which is limited to productive infections in humans and chimpanzees. Here, we will discuss different approaches that have been taken to study HBV and HDV infections in vivo. The development of transgenic and humanized mice has lead to deeper insights into HBV pathogenesis. An improved understanding of the determinants governing HBV and HDV species tropism will aid the construction of a small animal model with inheritable susceptible to HBV/HDV.