Effects of Cyclic and Continuous Total Enteral Nutrition on Circadian Cortisol Rhythm
Effects of Cyclic and Continuous Total Enteral Nutrition on Circadian Cortisol Rhythm
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循环和连续全肠内营养对皮质醇昼夜节律的影响
DOI：
10.3164/jcbn.2.83
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
H. Tanioka
中科院分区：
文献类型：
--
作者：
H. Kato;M. Saito;T. Shimazu;H. Ogase;H. Tanioka
为了阐明饮食摄入模式与肾上腺皮质昼夜节律之间的关系，我们在接受全肠内营养（TEN）约11天的两组患者中，以昼夜节律间隔测量了血浆皮质醇水平：其中一组在尿道内连续给予流质饮食另一组在每天0700- 2300小时间断地接受营养（周期性TEN）。在周期性TEN患者中，有一个明确的皮质醇节律，峰值在0700 h，该模式与正常受试者中观察到的明确的皮质醇节律非常相似。然而，连续性TEN患者没有表现出任何一致的昼夜皮质醇节律，尽管24小时平均皮质醇水平与周期性TEN患者几乎相同。在周期性TEN组中，血糖水平显示昼夜节律波动，但在连续性TEN组中保持相当恒定。这些结果表明，营养摄入的周期性是必不可少的昼夜皮质醇节律的维持和建议的重要性，饮食摄入的时间作为一个同步器（zeitgeber）的节奏在人，在实验室动物中提出。
To clarify relationships between the pattern of diet intake and the circadian adrenocortical rhythm, we measured plasma cortisol levels at circadian intervals in two groups of patients who had been receiving total enteral nutrition (TEN) for about 11 days: one group was given a liquid diet intraduodenally and continuously (continuous TEN), whereas the other received their nutrition discontinuously from 0700-2300h every day (cyclic TEN). In patients with cyclic TEN there was a clear cortisol rhythm with a peak at 0700h, which pattern is quite similar to the well-established cortisol rhythm seen in normal subjects. However, patients with continuous TEN did not show any consistent circadian cortisol rhythm, although the 24-h mean cortisol level was nearly the same as that in the case of cyclic TEN. Plasma glucose levels showed circadian fluctuations in the cyclic TEN group, but remained fairly constant in the continuous TEN group. These results indicate that the periodicity of nutrient intake is essential for the maintenance of the circadian cortisol rhythm and suggest the importance of the timing of diet intake as a synchronizer (zeitgeber) of the rhythm in man, as proposed in laboratory animals.