Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls
Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls
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DOI：
10.1007/s00259-014-2785-8
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发表时间：
2014-10-01
影响因子：
9.1
通讯作者：
la Fougere, Christian
中科院分区：
文献类型：
--
作者：
Koch, Walter;Unterrainer, Marcus;la Fougere, Christian
目的 除了与多巴胺转运蛋白 (DAT) 结合外，[I-123]FP-CIT 对血清素转运蛋白 (SERT) 表现出中等亲和力，允许在不同脑区的单次成像过程中对两种单胺转运蛋白进行成像。本研究的目的是系统地评估一大群健康对照者中的纹状体结合（主要是 SERT）及其年龄和性别依赖性。方法 使用丘脑和脑桥的感兴趣体积分析，对 103 名健康对照者的 SPECT 数据进行分析，这些数据具有明确的正常标准，这些数据是在 13 个不同的成像中心获得的。检查数据的性别和年龄影响以及纹状体 DAT 放射性示踪剂结合的潜在影响。结果丘脑结合显着高于脑桥结合。部分相关性显示壳核 DAT 结合对丘脑中测量的结合有影响，但对脑桥没有影响。数据显示纹状体外结合存在很大的个体差异。在丘脑中观察到了显着的性别影响，女性的结合力比男性高 31%，但在脑桥中没有观察到。显示了丘脑每十年下降 8.2 +/- 1.3 % 和脑桥 6.8 +/- 2.9 % 的年龄依赖性（+/- 标准误差）。 结论 使用健康对照中的 [I-123]FP-CIT 扫描大型数据库，显示了在单次成像过程中除了纹状体 DAT 之外评估纹状体外主要 SERT 结合的潜力。对于丘脑和脑桥，观察到放射性示踪剂结合与年龄相关的下降。仅在丘脑中的结合证明了性别效应。作为潜在的临床应用，当使用 [I-123]FP-CIT 对接受选择性 5-羟色胺再摄取抑制剂治疗的患者进行 DAT 成像时，除了黑质纹状体完整性之外，这些数据还可用作估计 SERT 占用率的参考。
Purpose Apart from binding to the dopamine transporter (DAT), [I-123]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls.Methods SPECT data from 103 healthy controls with well-defined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding.Results Thalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (+/- standard error) of 8.2 +/- 1.3 % for the thalamus and 6.8 +/- 2.9 % for the pons was shown.Conclusion The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [I-123]FP-CIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [I-123]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors.